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Soft capsule of ultra-micro powder and preparation method thereof

A soft capsule preparation and ultrafine pulverization technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of low bioavailability, poor absorption, and affecting the curative effect of Naokangtai Capsules

Inactive Publication Date: 2006-10-04
海口绿科南药研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Naokangtai capsules take a long time to disintegrate, and because the capsules contain raw medicinal powder, the absorption is poor and the bioavailability is low, which affects the curative effect of Naokangtai capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0026] Superfinely pulverize 0.3g musk, 45g safflower, and 45g earthworm; take 30g chuanxiong, 75g salvia, 45g zedoary, 45g peach kernel, and 45g trigonum, add water and decoct twice for 1.5 hours each time, combine the decoction, and concentrate to The thick paste is dried under reduced pressure and then ultrafinely pulverized; the above two are added into 400g of diluent (20g of beeswax is added to 380g of soybean oil), mixed evenly to make a medicinal solution. Get 500g of gelatin, 150g of glycerin and 500g of water to make glue. Utilize compression method, make 1000 soft capsules, get final product.

preparation example 2

[0028] Superfinely pulverize 0.3g musk, 45g safflower, and 45g earthworm; take 30g chuanxiong, 75g salvia, 45g zedoary, 45g peach kernel, and 45g trigonum, add water and decoct twice for 1.5 hours each time, combine the decoction, and concentrate to Thick paste, after decompression drying, ultrafine pulverization; The above two are added in 400g diluent (20g palm oil is added in 380g olive oil), mix well, make liquid medicine. Get 500g of gelatin, 150g of glycerin and 500g of water to make glue. Utilize compression method, make 1000 soft capsules, get final product.

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PUM

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Abstract

The invention provides a process for preparing soft capsules with reduced disintegrating period and improved biological availability, which is prepared from musk, Ligusticum wallichii, safflower, earthworm, root of red rooted saliva, zedoary and peach kernels as the raw material.

Description

technical field [0001] The invention relates to a traditional Chinese medicine soft capsule preparation and a preparation method thereof. The preparation is composed of musk, chuanxiong, safflower, earthworm, salvia miltiorrhiza, curcuma, peach kernel and trigonum. Background technique [0002] Naokangtai Capsules (WS-10481-(ZD-0481)-2002) has been used clinically. It is a compound preparation of traditional Chinese medicine. It is made of musk, Chuanxiong, safflower, earthworm, salvia miltiorrhiza, curcuma, peach kernel, and trigonum. The effect of removing blood stasis is clinically used for apoplexy, meridians and collaterals belonging to the syndrome of blood stasis blocking burns, and the syndrome is hemiplegia. [0003] Naokangtai capsule disintegrates for a long time, and because the capsule contains raw medicinal material powder, the absorption is poor and the bioavailability is low, which affects the curative effect of Naokangtai capsule. [0004] The present inven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/48A61P9/10A61P25/00A61K35/55A61K35/64A61K35/62
Inventor 滕厚雷
Owner 海口绿科南药研究开发有限公司