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Protein markers for human benign prostatic hyperplasia (BPH)

A technology for prostatic hyperplasia and protein labeling, applied in the field of human protein labeling of benign prostatic hyperplasia (BPH)

Active Publication Date: 2006-10-18
THE UNIVERSITY OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite its usefulness in prostate cancer diagnosis, PSA(hK3) is not tumor-specific

Method used

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  • Protein markers for human benign prostatic hyperplasia (BPH)
  • Protein markers for human benign prostatic hyperplasia (BPH)
  • Protein markers for human benign prostatic hyperplasia (BPH)

Examples

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Embodiment Construction

[0032] Embodiment of the invention

[0033] The present invention provides a method of diagnosing whether a subject suffers from benign prostatic hyperplasia (BPH), the method comprising obtaining a prostatic fluid sample from the subject, and analyzing the prostatic fluid sample to detect the presence or absence of a BPH protein marker to determine Whether the subject has BPH. In preferred embodiments, the subject is a human male. Secreted prostatic fluid samples were obtained by finger squeezing the patient's prostate gland through the rectal route. In one embodiment, the labeled protein is detected using two-dimensional electrophoresis and mass spectrometry. Specific antisera against these marker proteins were added. Protein markers can be detected using antibodies against the protein marker. In preferred embodiments, protein markers include PSP61, lwPSA or αs1-casein.

[0034] The present invention further provides a method for diagnosing whether a subject suffers fro...

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Abstract

The present invention provides a method of diagnosing whether a subject suffers from benign prostatic hyperplasia (BPH), the method comprising obtaining a prostatic fluid sample from the subject, and analyzing the prostatic fluid sample to detect the presence or absence of a BPH protein marker to determine Whether the subject has BPH. The present invention further provides a method of diagnosing whether a subject suffers from benign prostatic hyperplasia (BPH), the method comprising obtaining a serum sample from the subject, and analyzing the serum sample to detect the presence or absence of a BPH protein marker to determine whether the subject is suffering from benign prostatic hyperplasia (BPH). Whether the test subject has BPH. Finally, the present invention provides a diagnostic kit for detecting benign prostatic hyperplasia (BPH) markers containing BPH protein markers and instructions for use.

Description

[0001] This application claims priority to U.S. Provisional Application No. 60 / 485,653, filed July 8, 2003, and U.S. Provisional Application No. 60 / 498,623, filed August 27, 2003, the contents of which are incorporated herein as refer to. [0002] Throughout this application, various publications are cited by their author and date in parentheses. Full citations for said publications are listed at the end of the specification, just before the claims. The entire contents of these publications are incorporated into this application by reference in order to more fully disclose the prior art in the art as of the filing date of the applications described and claimed herein. technical field [0003] The present invention relates to novel protein markers for the detection of benign prostatic hyperplasia (BPH) and methods for the detection of BPH. Background of the invention [0004] Benign prostatic hyperplasia (BPH) is a common, increasing age-related disorder of the prostate gla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53G01N33/567G01N33/574G01N33/577G01N33/68
CPCG01N33/57434G01N33/6893G01N2800/342G01N33/53G01N33/577G01N33/68
Inventor 王云川许克新王向红
Owner THE UNIVERSITY OF HONG KONG
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