Use of triethylene-tetramine as antitumour auxiliary drug

A technology of triethylenetetramine and anti-tumor drugs, which is applied in the direction of anti-tumor drugs, drug combinations, and medical preparations containing active ingredients, etc. It can solve the problems of enhancing curative effect and accelerating tumor cell telomere shortening, so as to improve curative effect, Enhance the anti-tumor effect and reduce the effect of clinical dosage

Inactive Publication Date: 2006-10-25
CHONGQING TECH & BUSINESS UNIV
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Problems solved by technology

In addition, considering the mechanism of action of antineoplastic drugs, the combination of antineoplastic drugs with different mechanisms of action may also enhance the efficacy
Further research by Dr. Corey, a senior researcher at the University of Texas Southwestern Medical Center and professor of pharmacology and biochemistry, found that telomerase inhibitors can effectively slow down the formation of tumors within a few weeks, but if supplemented with conventional cancer drugs, such as Carboplatin (carboplatin) and cisplatin (cisplatin), telomerase inhibitors also have additional effects of inhibiting tumor cell proliferation, and will also accelerate the telomere shortening of tumor cells

Method used

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  • Use of triethylene-tetramine as antitumour auxiliary drug

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Embodiment Construction

[0029] The present invention will be further described below in conjunction with accompanying drawing:

[0030] In order to better understand the essence of the present invention, on the basis of analyzing the mechanism of action of triethylenetetramine inhibiting telomerase activity, conventional antitumor agents such as triethylenetetramine and paclitaxel, doxorubicin, and carboplatin will be determined by the MTT method. Antitumor effect of drugs in breast cancer MCF-7 and HELa cells. At the same time, the effect of triethylenetetramine combined with doxorubicin on the growth of B16 tumors in mice was analyzed:

[0031] (1) Triethylenetetramine inhibits telomerase activity and mechanism in breast cancer MCF-7

[0032] Experimental Materials

[0033] MCF-7, HeLa cells: purchased from the Cell Bank of Shanghai Institute of Cellular Sciences, Chinese Academy of Sciences

[0034] Silver staining kit: Promega

[0035] Serum, culture medium: DMEM, Hyclone company

[0036] Tr...

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Abstract

The present invention provides a new application of triethylene tetramine as auxiliary medicine for resisting tumor. It uses the triethylene tetramine as telomerase inhibitor and can be matched with other conventional antitumor medicines including doxorubicin, carboplatin and taxol, etc. for curing and preventing tumor diseases.

Description

technical field [0001] The invention relates to the application of triethylenetetramine, in particular to the application of triethylenetetramine as an anti-tumor auxiliary drug. Background technique [0002] Tumor (cancer) is the second largest "killer" after cardiovascular disease worldwide. In recent years, cancer chemotherapy has made considerable progress, and the survival time of cancer patients has been significantly prolonged, especially in the treatment of leukemia and malignant lymphoma. The treatment of solid tumors has not achieved satisfactory results. Pharmacists and oncologists have increasingly realized that in order to improve the curative effect of tumor treatment, we must start with the mechanism of tumor occurrence and development in order to achieve new breakthroughs. Over the past few years, the foreign medical community has gained a new understanding of the pathogenesis of tumor diseases on the basis of cells. For exa...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/132A61K31/282A61K31/337A61K31/704A61K45/06A61P35/00
Inventor 刘建辉殷菲陈刚郭莉霞郑旭煦
Owner CHONGQING TECH & BUSINESS UNIV
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