Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drop pills of cucurbitacine, and preparation method

A technology for cucurbitacin and vegetarian dropping pills, applied in the field of medicine, can solve the problems of low degree of pure naturalness, low degree of naturalness and low degree of naturalness of auxiliary materials for dropping pills, so as to reduce the irritating smell of drugs, improve the pH of the oral cavity, and improve the The effect of mouth odor

Inactive Publication Date: 2006-12-06
TIANJIN TASLY PHARMA CO LTD
View PDF1 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as application number: 200310113362.3, application date: 2003.11.17 patent literature provides a kind of dripping pill medicine for diseases such as chronic persistent hepatitis, chronic active hepatitis, initial liver cirrhosis, liver poisoning and provides a preparation method, the dropping pill The drug uses polyethylene glycol and other auxiliary materials to make cucurbitacin into drop pills; although the drop pill overcomes the defects of the current tablet and accelerates the dissolution rate, the drop pill has the defect that the natural degree of the auxiliary materials used is not high
[0004] With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The preparation is a kind of high-efficiency, quick-acting new Chinese medicine preparation, which overcomes the shortcomings and deficiencies of the previous Chinese medicine preparations, but the current drop pill preparations generally face the following problems: 1. The natural degree of drop pill auxiliary materials is not high: at present, the drop pill matrix Most of the excipients are chemical synthetic products with a low degree of naturalness. It is very difficult to find new alternative matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, because currently common and possible The preparation conditions required for the substitutes of natural matrix excipients are very harsh, and the temperature of excipients and the droplet dripping conditions are the key factors affecting the preparation of droplet pills
If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work
2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, looking for One or more new matrix excipients that can be accepted by the international market are particularly important and urgent
3. Disadvantages of mouthfeel and speed of onset of action: Poor taste of traditional Chinese medicine and its preparations is one of its major characteristics. When people take certain medicines, they are far more afraid of the bad taste of the medicine than they are of the disease. What's more, some patients give up the treatment of traditional Chinese medicine because they can't overcome the bad taste or smell of traditional Chinese medicine or its preparations. For example, making the medicine into capsules or sugar-coated tablets can improve the taste and reduce stimulation, but the disintegration speed is prolonged. , which is not conducive to the rapid onset of the drug, and is not suitable for some diseases, especially those that require the rapid onset of the drug
4. Difficult preparation process for industrial production of dripping pills: In the replacement process of dripping pill preparation auxiliary materials, it is very difficult to determine the preparation process for industrial production, such as the melting temperature of matrix auxiliary materials, dripping temperature, auxiliary materials and The ratio of the drug, the ratio of the caliber of the dropper, and the condensing agent are all factors that affect the drop pills. Therefore, it is time-consuming and expensive to replace the matrix and be suitable for industrial production.
[0005] In order to change the long-term situation that the base auxiliary materials of dropping pills are mainly chemically synthesized auxiliary materials, solve the problem that the base of dropping pills is currently facing a low degree of naturalness, which is increasingly unable to satisfy people. It is required to return to nature, take the problem of pure natural medicine with low toxicity and no side effects; it can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, and enhance the competitiveness of the international market; A large number of experiments and research on preparation technology have invented a pure Chinese medicine dripping pill preparation with low toxic and side effects, significant curative effect, moderate price and suitable for industrialized large-scale production.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (a) Take cucurbitacin 1.0g, xylitol 18.3g, and starch 6.7g for subsequent use;

[0053] (b) Mix xylitol and starch evenly, add the above-mentioned cucurbitacin and mix thoroughly, heat and melt the mixture at 64°C, stir evenly, and stir for 10 to 30 minutes, keep warm, drip at 64°C, and the diameter of the dropper is 1.2 to 2.5 mm, drop into methyl silicone oil at 0°C to make 1000 drop pills, drain the drop pills and wipe off the cooling liquid.

Embodiment 2

[0055] (a) Take 20 g of cucurbitacin, 70.9 g of lactitol, and 23.1 g of starch for subsequent use;

[0056] (b) Mix lactitol and starch evenly, add the above-mentioned cucurbitacin and mix thoroughly, heat and melt the mixture at 64°C, stir evenly, and stir for 10 to 30 minutes, keep warm, drop at 64°C, and the diameter of the dropper is 1.2 ~2.5 mm, drop into 0 ℃ methyl silicone oil to make 3000 drop pills, drain the drop pills and wipe off the cooling liquid, that is to say.

Embodiment 3

[0058] (a) get cucurbitacin 40g, xylitol 71.4g, gum arabic 28.6g for subsequent use;

[0059] (b) Mix xylitol and gum arabic evenly, add the above-mentioned cucurbitacin and mix well, heat and melt the mixture at 64°C, stir evenly, stir for 10 to 30 minutes, keep warm, drip at 64°C, dropper caliber 1.2 to 2.5 mm in diameter, drop into methyl silicone oil at 0°C to make 4000 drop pills, drain the drop pills and wipe off the cooling liquid.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A dripping pill of cucurbitacin for treating chronic metastatic hepatitis features high natural level and safety and low toxic by-effect. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine for treating chronic persistent hepatitis prepared from traditional Chinese medicines. Background technique [0002] Cucurbitacin is extracted and refined from the fruit stalk of Cucurbitaceae plant muskmelon (Cucumis melo L.), and its pharmacological studies have shown that it has hepatoprotective and anti-hepatitis effects; Therefore, it has been widely used clinically, and has played a positive role in the treatment of diseases such as hepatitis. Diseases such as persistent hepatitis, chronic hepatitis, and liver cancer have seriously affected the quality of human life, threatened human health, and brought serious burdens to families and society. More and more people suffer from liver diseases, and their harmfulness is also increasingly prominent. Effective Prevention and treatment of diseases such as hepatitis has become an important topic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61K9/20A61P1/16A61P31/14A61P35/00
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products