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Micro passageway biological chip

A biochip and microfluidic technology, which is applied in the direction of microbial measurement/inspection, biological testing, biochemical equipment and methods, etc., can solve the problems of increased chip manufacturing costs, unsuitable for disposable use, etc.

Inactive Publication Date: 2007-04-18
IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the manufacturing cost of the chip increases, so it is not suitable for disposable use

Method used

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  • Micro passageway biological chip
  • Micro passageway biological chip
  • Micro passageway biological chip

Examples

Experimental program
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Embodiment Construction

[0039] The invention provides a biological chip with a micro flow channel, which at least includes a substrate with an upper surface and a lower surface and a cover plate covering the upper surface of the substrate. The substrate has a plurality of micro flow channels formed on the upper surface of the substrate.

[0040] In order to understand the influence of different slopes on micro-channel fluid, the present invention designs micro-channel chips with three different slopes, which are micro-channels with positive slope, flat slope (slope is zero) and negative slope. FIG. 1A is a top view of a biochip with three different sloped microfluidic channels of the present invention. FIG. 1B is a partial cross-sectional view of the microchannel with a positive slope in the biochip of FIG. 1A .

[0041] As shown in FIG. 1B , the biochip 1 at least includes a substrate 10 and a cover 20 covering the upper surface 10 a of the substrate. The material of the substrate 10 is, for examp...

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Abstract

The invention relates to micro flow passage biochip. It uses incline type micro flow passage to control fluid, go forward in order to process cell medicine detecting. Because of the flow resistance change caused by the incline micro flow passage is continuous, the fluid will not be stagnated while it going forward. It can increase reaction consistency of the reagent in each micro flow passage to increase cell reaction time correctness while medicine testing. And it also can match with sub-channel to further control fluid flow into or out the micro flow passage at the same time.

Description

technical field [0001] The invention relates to a structure of a biological chip, and in particular to a structure of a biological chip with a plurality of microfluidic channels. Background technique [0002] Cells are the most basic unit of organisms, with precise configuration and complex biochemical reactions, making it difficult to artificially imitate and replicate. Cells play an important role in drug development. The interaction between drugs and cells causes a series of changes in the external morphology and internal metabolic process of cells. Through the detection and analysis of drugs on cells, the mechanism of action of drugs can be speculated and the activity and toxicity of drugs can be evaluated. . Due to the complexity of the human body system, in order to understand the effects of drugs on the human body, it is usually tested at the cellular level; and because the cell response is direct, sensitive and easy to observe, researchers usually infer the possible...

Claims

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Application Information

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IPC IPC(8): G01N35/00G01N33/50C12Q1/00
Inventor 庞绍华
Owner IND TECH RES INST