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Method and device for decoupling and/or desynchronizing neural brain activity

A desynchronized, active technology, applied in spinal nerve electrodes, applications, electrotherapy, etc.

Inactive Publication Date: 2012-08-22
FORSCHUNGSZENTRUM JULICH GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The stimulation methods described above require the use of one or more depth electrodes, which represent a high surgical workload and a high risk of complications, like e.g. possible brain tissue damage or cerebral hemorrhage during implantation of the depth electrodes in the patient

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  • Method and device for decoupling and/or desynchronizing neural brain activity
  • Method and device for decoupling and/or desynchronizing neural brain activity
  • Method and device for decoupling and/or desynchronizing neural brain activity

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Embodiment Construction

[0029] exist figure 2 In a-d and 3a-d, the abscissa indicates the time axis in seconds, while along the ordinate, the measured neural activity ( figure 2 a, 3a) or excitation mode ( figure 2 b, 3b) or sync range ( figure 2 c, 3c) or the sum of coupling and stimulus effects ( figure 2d, 3d) In each case plotted in arbitrary units. Neural activity measured via sensor 3 ( figure 2 a, 3a) are used as a basis for generating stimulus excitations. exist figure 2 In e and 3e, the abscissa indicates the frequency, while the ordinate indicates the relative number of neurons with the corresponding frequency.

[0030] according to figure 1 The device comprises an isolation amplifier 1 connected to electrodes 2 and at least one sensor 3 for detecting physiological measurement signals. The electrodes 2 used can be, for example, cortical electrodes or brain electrodes. The isolation amplifier is also connected to a unit 4 for signal processing and control, which is connected ...

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Abstract

The invention relates to a device for decoupling and / or desynchronizing neural, pathologically synchronous brain activity, in which the activities in a partial region of a brain area or a functionally associated brain area are stimulated by means of an electrode, surprisingly resulting in decoupling and desynchronization of the targeted neuron population from the patient's pathological area whilethe symptoms are suppressed. In an alternative embodiment of the inventive device, the pathologically synchronous brain activity is desynchronized, which also results in the symptoms being suppressed. The feedback stimulation signal, i.e. the measured, delayed, and processed neural activity, is used as a stimulus, whereby the stimulation signal is controlled on demand in a self-regulating manner such that the magnitude of the resulting stimulating influence on the neural population that is to be decoupled or desynchronized is automatically minimized once decoupling and / or desynchronization has been successful. The inventive device does not need to be calibrated with great effort nor do the stimulation parameters need to be regulated in order for the device to be operated successfully; however, said stimulation parameters can preferably be adjusted and optimized with the aid of an additional controller. The disclosed device comprises a stimulation electrode (2) and at least one sensor (3) which are triggered using a controller so as to cause decoupling and / or desynchronization in the local environment thereof.

Description

technical field [0001] The invention relates to a device for decoupling and / or desynchronizing neural brain activity, as stated in the preamble of claim 1 . Background technique [0002] Pathologically synchronized brain activity, which can have its origin eg in the basal ganglia, can also generate synchronization as a driving force in following areas like eg the motor cortex. This secondary synchronization is significantly involved in generating pathological symptoms. The present invention relates to a device that allows the decoupling of the driving pathological activity from the following area, thereby implying that a substantial reduction of pathological symptoms can be caused. In a further embodiment, the device according to the invention can also be used for desynchronization, i.e. for the suppression of rhythmic collective activity, or respectively for the neurogenesis of pathologically synchronized populations of neurons called driving populations. The collective e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N1/36A61B5/0476A61B5/00A61B5/374A61N1/05
CPCA61N1/36146A61N1/0551A61B5/0006A61N1/36067A61N1/36082A61N1/36135A61B5/726A61N1/06A61B5/7225A61B5/048A61B5/4082A61B5/374
Inventor 彼得·塔斯奥列克山大·波波维奇克里斯蒂安·豪普特曼瓦莱里·克拉奇科夫斯基
Owner FORSCHUNGSZENTRUM JULICH GMBH
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