Transdermal absorption formulation of total alkaloid of common monkshood root and preparation process thereof

A transdermal absorption preparation and total alkaloid technology, applied in anti-inflammatory agents, drug combinations, pharmaceutical formulas, etc., can solve the problems of patients' psychological burden, inconvenient use of black plaster, and large skin irritation, so as to avoid first-pass Effects and adverse reactions such as gastrointestinal tract, reducing the number of administrations, and the effect of constant blood concentration

Inactive Publication Date: 2007-05-30
HARBIN UNIV OF COMMERCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing methods of administration of traditional Chinese medicines containing aconitum mainly include injections, tablets, pills, decoctions, powders, black plasters, etc. Since oral preparations are prone to first-pass effects in the gastrointestinal tract and are toxic to liver cells, injections are easy to release Pain and lumps occur at the injection site, and the frequency of use is frequent, which is easy to cause psychological burden on the patient. The traditional black plaster is inconvenient to use, has strong skin irritation, and many allergic reactions. The transdermal drug delivery system has a long medication time and avoids the first-pass effect. , reduce adverse drug reactions and easy to use, it is an ideal dosage form
At present, there are very few studies on the transdermal properties and formulations of total alkaloids of Aconitum alkaloids at home and abroad.

Method used

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  • Transdermal absorption formulation of total alkaloid of common monkshood root and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Multilayer Reservoir Matrix Drug Delivery System

[0040] 1. This embodiment includes four parts: a reservoir layer, an adhesive layer, a backing layer and a protective layer, wherein the drug reservoir layer of the reservoir layer includes two layers: a drug reservoir layer 1 and a drug reservoir layer 2, and the weight of the drug reservoir layer 1 is The ratio is: 0.21 part of total alkaloid extract of Chuanwu, 2 parts of PVA+PVP (2:1) solution, 0.3 part of propylene glycol, 0.03 part of azone, and 0.46 part of others; the weight ratio of drug storage layer 2 is: 0.15 part of alkaloid extract, 1.50 part of pressure-sensitive adhesive, 0.30 part of propylene glycol, 0.03 part of azone, and 1.12 part of others; the adhesive layer includes 1 part of pressure-sensitive adhesive and 0.1 part of thickener. The other component in this example is water.

[0041] 3. The process is:

[0042] After heating and dissolving the drug in the drug storage layer 1 with wa...

Embodiment 2

[0044] Example 2: Polymer Matrix Drug Delivery System

[0045] 1. This embodiment includes four parts: a reservoir layer, an adhesive layer, a backing layer and a protective layer, wherein the drug reservoir layer of the reservoir layer includes: 0.30 part of the total alkaloid extract of Chuanwu, PVA+PVP (2:1 ) solution 2 parts, propylene glycol 0.40 parts, azone 0.04 parts, other 1.26 parts; the adhesive layer includes 2 parts of pressure sensitive adhesive and 0.5 part of thickener.

[0046] The other component in this example is water.

[0047] 2. The process is:

[0048]Mix the drug in the drug storage layer, the skeleton material solution and the penetration enhancer evenly, place it on a clean, flat and smooth glass plate to form a thin film, dry at 60-80 °C, release the film, and stick it on the release paper that has been removed. , mix the pressure-sensitive adhesive and thickener, lay a film on the release paper, dry it, and laminate the drug storage layer and the...

Embodiment 3

[0050] Example 3: Adhesive matrix drug delivery system

[0051] 1. This embodiment includes four parts: a reservoir layer, an adhesive layer, a backing layer and a protective layer, wherein the drug reservoir layer of the reservoir layer includes: 0.30 part of the total alkaloid extract of A. 0.40 part, azone 0.04 part, other 1.26 part. The other component in this example is water.

[0052] 2. The process is:

[0053] Mix the drug, pressure-sensitive adhesive, and penetration enhancer in the drug storage layer evenly, heat and defoaming, place it in a mold padded with release paper, lay the film, remove the mold, dry at 80 °C for 2 hours, and paste it on Reinforced sticker with release paper removed, and that's it.

[0054] Others are the same as in Example 1.

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Abstract

The invention discloses a frame type percutaneous absorption externally-used preparation and process for preparing it, which comprises four portions of a storage layer, an adhesive layer, a back lining layer and a protection layer, wherein the storage layer comprises the following constituents (by weight ratio): Ligusticum wallichii alkaloid extract 7.5-12 parts, frame material 50-60 parts, methyl glycol 7-15 parts, azone 0.5-3 parts, and thickening agent 0-5 parts, other ingredients 5-35 parts. The preparation can be used for treating rheumatic and rheumatoid arthritis.

Description

(1) Technical field [0001] The invention relates to a TDS preparation for external use, in particular to a skeleton-type transdermal absorption preparation with total alkaloids of Chuanwu as main drug and a preparation process thereof. (2) Background technology [0002] Rheumatism and rheumatoid arthritis belong to the category of "regular section" and "stubborn arthralgia" in traditional Chinese medicine. In the medical history books, various famous and proven prescriptions for pain treatment all use Aconitum as the monarch medicine. For example, the article "Stroke Calendar Disease" in "The Synopsis of the Golden Chamber" says, "The pain of flexion and extension in the medical record festival cannot be controlled, and Wutou Tang is the main medicine." The power of expelling cold and dampness is very fast" ("Changsha Medicine Solution"), and it is good at entering the meridians, and its power can clear the stagnant yin and condense cold. Modern pharmacological tests show ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K31/439A61K9/70A61K47/32A61M37/00A61P19/02A61P19/04A61P29/00A61K125/00
Inventor 李文兰季宇彬王艳萍赵培范玉奇
Owner HARBIN UNIV OF COMMERCE
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