Nano metal chiral identification solid phase, chiral separation chromatograph and its preparation method

Abstract

Precious metal ionic nanometer particles and chirality chromatographic fractionation meter starts from making particle solution and metal chirality identification fixed phase fixing it on the capillary tube or micro flow channel through its core plate to get the chirality chromatographic fraction meter. Compared with existing devices, it is simple and feasible in manufacturing, with moderate processing temperature. With highly efficient separation, it shortens the chirality separation period with stability and endurability. It applies to areas that have higher requirements for chirality separation efficiency.

Description

Technical field:

[0001] The invention belongs to the field of preparation methods of chiral chromatographic columns, in particular to a nanometer metal chiral recognition stationary phase, chiral separation chromatographic columns and a preparation method. Background technique:

[0002] Chiral isomers refer to two chemical compounds whose molecular structures are mirror images of each other but cannot be superimposed. They are called enantiomers. The two chiral molecular formulas are exactly the same, but the spatial orientation of atoms and atomic groups is different. Enantiomers have essentially the same chemical and physical properties in an achiral environment. However, some chiral isomers have huge differences in toxicity, pharmacology and biological metabolism. As far as the field of pharmacy is concerned, as many as 30% to 40% of drugs are chiral. Differences in biological activity or pharmacokinetics of chiral isomers make separation of chiral enantiomers particula...

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