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Method of powdering supercritical CO2 solid extract

A carbon dioxide, solid powder technology, applied in the direction of making medicines into special physical or taking forms of devices, etc., can solve problems such as easy deterioration, and achieve the effects of not easy to deteriorate, good fluidity, and uniform content

Active Publication Date: 2007-06-06
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the supercritical carbon dioxide extract mainly contains lipophilic components, it exists in one or more mixed forms of liquid oil, semi-solid grease, and solid crystals at room temperature. When the extract is made into tablets, capsules, granules, pills, etc. In the process of solid dosage forms, there are the following problems: (1) The extract contains a certain amount of water, which is easy to deteriorate during storage; (2) It is difficult to mix the extract evenly with other materials when it is added by conventional spraying or blending methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Take 1 kg of angelica supercritical carbon dioxide extract (liquid), add 0.4 kg of micropowder silica gel, stir and mix evenly, squeeze through a sieve with a mesh size of 100 or more, and mix evenly to obtain the solid powder of angelica supercritical carbon dioxide extract.

Embodiment 2

[0011] Take 1 kg of jasmine supercritical carbon dioxide extract (semi-solid oil), add 0.5 kg of micropowder silica gel, stir and mix evenly, squeeze through a sieve with a mesh size of 100 or more, and mix evenly to obtain the solid powder of jasmine supercritical carbon dioxide extract.

Embodiment 3

[0013] Take 1 kg of magnolia magnolia supercritical carbon dioxide extract (crystals are contained in the semi-solid oil), add 0.5 kg of ethyl acetate, stir to dissolve, then add 0.5 kg of micropowder silica gel, stir and mix evenly, squeeze through a sieve above 100 mesh, Mix evenly, and evaporate the ethyl acetate at 40°C to obtain the solid powder of supercritical carbon dioxide extract of Magnolia officinalis.

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PUM

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Abstract

The present invention relates to medicine preparing technology, and is especially method of powdering supercritical CO2 extracted solid. For extract containing no crystal, the method includes adding fine silica gel powder via stirring, extruding the mixture through 100 mesh sieve and further mixing to obtain the extract powder. For extract containing crystal, the method includes dissolving the extract in solvent through stirring, adding fine silica gel powder via stirring, extruding the mixture through 100 mesh sieve, volatilizing solvent at 50 deg.c and further mixing to obtain the extract powder. The powdered extract thus obtained has high flowability, homogeneous content, less degeneration, easy mixing with other material, and other advantages.

Description

technical field [0001] The invention relates to a pharmaceutical preparation technology, in particular to a method for solid powdering supercritical carbon dioxide extract. Background technique [0002] At present, supercritical carbon dioxide extraction technology is widely used in the extraction of traditional Chinese medicine and natural medicine. Since the supercritical carbon dioxide extract mainly contains lipophilic components, it exists in one or more mixed forms of liquid oil, semi-solid grease, and solid crystals at room temperature. When the extract is made into tablets, capsules, granules, pills, etc. In the process of solid dosage forms, there are the following problems: (1) the extract contains a certain amount of water, which is easy to deteriorate during storage; (2) the extract is difficult to mix evenly with other materials when it is added by conventional spraying or blending methods. After many years of research, the inventor of the present application h...

Claims

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Application Information

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IPC IPC(8): A61J3/02
Inventor 谭登平陈向东刘法锦
Owner GUANGDONG YIFANG PHARMA