Unlock instant, AI-driven research and patent intelligence for your innovation.

Topical composition for delivery of salicylate esters or salicylate salts

A technology of salicylic acid ester and composition, which is applied in the direction of salicylic acid active ingredient, drug combination, ointment delivery, etc.

Inactive Publication Date: 2007-06-20
KANGFA
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This system contains hydrophobic long-chain aliphatic amines which are exceptionally toxic and therefore should only be used in limited cases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Topical composition for delivery of salicylate esters or salicylate salts
  • Topical composition for delivery of salicylate esters or salicylate salts
  • Topical composition for delivery of salicylate esters or salicylate salts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-14

[0074] The preparation of embodiment 1-14-methyl salicylate ointment

[0075]1. Emulsion Preparation

[0076] A. Oil Phase Preparation: Combine all components except water while mixing and heating with a water bath (50-60° C.) to obtain a clear and transparent solution.

[0077] B. Add hot water (60-90° C.) to the oil phase and obtain a water-in-oil (W / O) type emulsion. The emulsion was mixed for 5-10 minutes using a propeller type mixer. During subsequent cooling, when the temperature drops below the cloud point of the surfactants in the mixture, the emulsion changes its physical structure, transitioning from a W / O emulsion to an O / W emulsion. The results of Examples 1, 2 and 4-7 resulted in the formation of unstable emulsions, whereas the formulations in Examples 3, 8-14 corresponded to stable oil-in-water emulsions. In one embodiment, the ratio between the oil and the salicylate component is optimized with respect to the hydrophilic-lipophilic balance (HLB) of the surf...

Embodiment 15

[0094] Table 3: Ethyl salicylate composition

[0095] oil phase

[0096] Ethyl Salicylate 12%

[0097] Myvacet9-45K 4%

[0098] L-Menthol 6%

[0099] D,L-camphor 6%

[0100] Vitamin E Acetate 4%

[0101] Lecithin S-80 1%

[0102] Ethanol 1%

[0103] Solutol HS-15 4%

[0104] Tocophersolan 4%

[0105] Aqueous phase 58%

[0106] Total 100%

[0107] Emulsion Stability +++

Embodiment 16

[0109] Table 4: Octyl Salicylate (Ethylhexyl Salicylate) Composition

[0110] oil phase

[0111] Octyl Salicylate 10%

[0112] MCT Oil 6%

[0113] L-Menthol 6%

[0114] D,L-camphor 6%

[0115] Vitamin E Acetate 2%

[0116] Lecithin S-80 1%

[0117] Ethanol 1%

[0118] Cremophor RH-40 5%

[0119] Tocophersolan 4%

[0120] Aqueous phase 59%

[0121] Total 100%

[0122] Emulsion Stability ++

[0123] Examples 15 and 16 were prepared in a manner similar to that of Examples 1-14.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The present invention provides a self-emulsifiable composition and a stable topical emulsion comprising same, which comprises salicylate esters, oils and surfactants and which does not require organic solvents. The invention also provides methods for manufacturing the compositions. The topical compositions of the invention can be used to enhance delivery of salicylate esters and are useful in the prevention and treatment of pain and inflammation.

Description

field of invention [0001] The present invention relates to a topical composition for the delivery of a salicylate or salt, a process for its preparation and related methods and uses. Background of the invention [0002] Various types of topical compositions in the form of lotions, creams, ointments, liniments, oils, balms, and solutions are known to relieve arthritis pain, muscle aches, neck tenderness, back pain, tendonitis, and slippery bursitis. Such dosage forms typically include a combination of anti-inflammatory or other analgesic, anti-irritant and organic solvent with volatile oil as a penetration enhancer. The efficacy of these medicines for treating pain still cannot meet the needs. [0003] US Patent 6,528,076, entitled "Topical Compositions and Methods for Treating Pain," discloses topical compositions for treating pain and methods of use thereof, wherein the compositions include effective amounts of acetone, a lubricant, and a salicylate-based compound. [00...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/60A61P29/00
CPCA61K36/38A61K31/60A61K47/22A61K47/24A61K36/45A61K47/44A61K36/28A61K9/06A61K47/14A61K9/0014A61K9/1075A61P29/00A61K2300/00
Inventor J·施瓦茨M·韦斯帕皮尔
Owner KANGFA