Topical zinc compositions and methods of use

a zinc composition and composition technology, applied in the field oftopical zinc compositions, can solve the problems of slow cell replication, inhibit tissue repair, and inability to readily be used in metabolic processes, and achieve the effect of low skin irritation, high zinc ion availability

Inactive Publication Date: 2003-04-24
ALLTERRA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

0023] The composition of the present invention includes (1) a pharmaceutically acceptable zinc compound, preferably zinc oxide or a divalent zinc complex, (2) a select amino acid, preferably glycine, and (3) a pharmaceutically acceptable carrier base, such as a solid or semi

Problems solved by technology

Diminished zinc availability slows protein synthesis, thereby slowing the replication of cells and inhibiting tissue repair.
Approximately half of the total body zinc content of 2-3 gm (based on an average 70 kg adult) is found in ossified tissues and is, therefore, not readily available for metabolic processes.
Although the skin boasts a higher zinc concentration than most tissues (10 micrograms/g of tissue), this is quickly depleted during the regeneration process.
Oral preparations of several zinc salts have been shown to reduce the symptoms and duration of the common cold caused by rhinovirus, but they are unpalatable and cause mouth irritation and nausea.
Unfortunately, topical application of some zinc solutions can cause painful or irritating side effects if not used in very low concentrations.
Zinc

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Zinc-Containing Moisturizing Cream with Vitamin E and Cocoa Butter

[0034] A moisturizing cream base was prepared containing the following ingredients: purified water, sunflower oil, stearic acid, cocoa butter, monoglyceryl stearate, stearic triglyceride, stearyl alcohol, aloe barbadensis gel, jojoba oil, .alpha.-tocopheryl acetate (Vitamin E), carrot extract, jasmine extract, chamomile extract, calendula extract, red clover blossom extract, methyl paraben, propyl paraben, caramel, retinyl palmitate and fragrance oil. The base ingredients were utilized in conventional amounts in view of the purpose to provide a moisturizing cream. A mixture of 0.440 g zinc oxide and 4.05 g anhydrous glycine was dissolved in 6.8 g purified water by heating in a Pyrex beaker to 160.degree. F. in a 750 watt microwave oven. The clear, hot solution was added to 115 g of the cream base and was blended thoroughly to a smooth opaque cream which contained 0.279% Zn.sup.2+. The product had acceptable consistenc...

example 2

Aloe Vera Ointment Containing Zinc

[0036] A 35.5 g aloe vera ointment base (including water, glyceryl stearate, PEG-100 stearate, glycerine, aloe vera gel, magnesium aluminum silicate, PEG-150 distearate, stearyl alcohol, quaternium 15, fragrance oil, diazolidinyl urea, and methyl paraben) was combined with 0.187 g zinc oxide and 1.73 g glycine dissolved in 2.9 g purified water at 160.degree. F. in a small Pyrex bowl. The stirred mass was warmed to 110-115.degree. F., at which point the mixture could be evenly blended to a smooth, translucent ointment by rubber spatula. The zinc content of the product was 0.37%. The product had acceptable flavor, consistency and astringency without causing irritating effects upon application.

example 3

Vitamin E Ointment with Zinc

[0037] A 45.4 g Vitamin E ointment base including petrolatum, isopropyl myristate, .alpha.-tocopheryl acetate (Vitamin E acetate), candelilla wax, cetyl alcohol, retinyl palmitate (Vitamin A palmitate), lecithin, and natural fragrance was combined with 0.180 g zinc oxide and 1.67 g glycine (dissolved in 2.8 g purified water at 160.degree. F.) in a small Pyrex bowl and blended together by vigorous stirring with a rubber spatula. The product was a smooth, pale, yellow, and slightly-translucent ointment. The zinc content of the product was 0.29%. The product had acceptable consistency, flavor and astringency without causing irritating effects upon application.

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Abstract

Compositions including zinc compounds and select amino acids in a carrier base, and methods of skin treatment with such compositions, are described. The compositions are useful for healing skin and minimizing the irritation incurred from contact with the zinc compound without loss of zinc availability during absorption into the integument.

Description

[0001] The present invention relates to zinc-containing compositions and methods for topical use of such compositions to treat cutaneous wounds, irritations, lesions, abrasions or the like. More particularly, the invention relates to zinc-containing compositions containing an amino acid to minimize external irritation from the zinc when applied to the skin without diminishing the amount of free zinc available for absorption.[0002] The value of zinc in tissue growth and repair is well documented. Zinc is essential for the function of at least 70 enzymes and is involved in a variety of metabolic processes. Zinc is a limiting factor in the formation of RNA and DNA. Zinc is also a limiting factor in zinc-dependent enzymes such as RNA and DNA polymerases, deoxythymidine kinase, and reverse transcriptase, which are responsible for the regulation of RNA and DNA metabolism. Diminished zinc availability slows protein synthesis, thereby slowing the replication of cells and inhibiting tissue r...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61KA61K9/08A61K9/10A61K9/70A61K31/195A61K31/198A61K31/315A61K31/555A61K33/00A61K33/30A61K33/32A61K47/00A61K47/18A61P17/00A61P17/02
CPCA61K33/30Y10S424/06Y10S514/922Y10S514/836A61K31/198Y10S514/974A61K2300/00A61P17/00A61P17/02
Inventor GODFREY, HELEN REBECCA
Owner ALLTERRA
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