Composition and method for reducing the risk or progression of cardiovascular, glaucoma and tardive dyskinesia diseases

Abstract

Elevated levels of homocysteine have been implicated as an important risk factor for cardiovascular and other diseases. A composition for decreasing levels of plasma homocysteine and a method for administering the composition are provided the composition containing dextromethorphan (DM), folic acid and vitamins B6 and B12. The composition provides a synergistic therapeutic effect so that lower amounts of the above ingredients may be employed to minimize any undesirable side effects caused by the use of high levels of a component such as DM. Preferred compositions for cardiovascular diseases further include lecithin, vitamin E, beta-carotene, procyanidins / flavonoids, trimethylglycine, garlic oil and minerals. Other compositions for treating glaucoma include bilberry, bioflavonoids and beta-carotene and for treating tardive dyskinesia include an antioxidant such as grape seed extract and pine bark extract, lecithin and oligomeric proanthocyanidins. The compositions may be administered using any suitable means such as orally or intravenous.

Description

[0001] 1. Field of the Invention[0002] The present invention relates to a composition and method for reducing the risk or progression of cardiovascular, glaucoma and tardive dyskinesia diseases and, more particularly, to a composition containing a number of ingredients which are present in amounts lower than amounts considered harmful to the body but which act synergistically to provide enhanced disease inhibition.[0003] 2. Description of Related Art[0004] Cardiovascular disease is the most frequent cause of death in industrialized countries. Atherosclerosis (AS) is the principal cause of cardiovascular disease. AS is a disease of the intima of the arteries that leads to fatty lesions called artheromatous plaques on the inside surface of the arteries. This deposit of fat and cholesterol narrows the arteries, and often becomes calcified, providing sites for abnormal blood clots to form, leading to high blood pressure, heart attacks and strokes.[0005] Elevated plasma homocysteine (Hcy...

AI Technical Summary

Benefits of technology

"The present invention is a composition and method for reducing the risk and progression of cardiovascular, glaucoma, and tardive dyskinesia diseases. The composition contains a mixture of ingredients that work synergistically to lower the levels of homocysteine, a marker for increased risk of these diseases. The ingredients include dextromethorphan, a noncompetitive antagonist of the NMDA receptor, and folic acid, B.sub.6, and B.sub.12, which are important for reducing Hcy levels. The composition is safe and effective in reducing the risk of these diseases."

Problems solved by technology

This deposit of fat and cholesterol narrows the arteries, and often becomes calcified, providing sites for abnormal blood clots to form, leading to high blood pressure, heart attacks and strokes.

Elevated plasma homocysteine (Hcy) concentrations have repeatedly been associated with increased vascular risk.

However, epidemiological data reveals that Hcy levels above 6.3 cause a steep progressive risk of heart attack.

The amount of DM necessary to reduce Hcy to safe levels can cause undesirable side effects however.

Vitamin supplements of folic acid, B.sub.6 and B.sub.12 have been shown to be useful in lowering Hcy but there is evidence that for some elderly people it is not sufficient to keep the level of Hcy low enough to be out of the danger zone.

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