Claudins as markers for early detection, diagnosis, prognosis and as targets of therapy for breast and metastatic brain or bone cancer

a breast cancer and marker technology, applied in the field of breast cancer diagnosis, prognosis, and treatment, can solve the problems of limited efficacy of breast cancer treatment in patients, few effective therapies for metastatic brain or bone cancer are currently available, etc., to stimulate cell migration and reduce cell-to-cell adhesion
US20050074798A1Inactive Publication Date: 2005-04-07THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
US ยท United States
Current Assignee / Owner
THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Publication Date
2005-04-07
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

Methods of diagnosis, prognosis, and treatment of breast cancer, and of metastatic brain cancer, are provided The diagnostic and prognostic methods involve the immunohistochemical detection of the level of expression of the proteins claudin 1, 3, 4, and 7 in tissue or cell samples. Claudins 1 and 7 are underexpressed in the majority of breast cancers, and claudins 3 and 4 are overexpressed. The methods of treatment involve the use of Clostridium perfringens enterotoxin (or a variant thereof) to lyse metastatic cancer cells in the brain and bone that overexpress claudins 3 and 4.
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Description

[0001] This application claims priority to international patent application PCT / US03 / 04371, filed Feb. 14, 2003, which in turn claims priority to U.S. provisional patent application 60 / 356,860, filed Feb. 14, 2002 and 60 / 424,222, filed Nov. 6, 2002, the complete contents of which are hereby incorporated by reference.

[0002] This invention was made using funds from grants from the Department of Defense having grant numbers DAMD17-01-0285 and DAMD17-02-1-0429. The United States government may have certain rights in this invention.BACKGROUND OF THE INVENTION

[0003] 1. Field of the Invention

[0004] The invention generally relates to the diagnosis, prognosis, and treatment of cancer. In particular, the invention provides the use of claudin proteins as targets for detection and treatment of primary epithelial cancers and metastatic brain and bone cancer.

[0005] 2. Background of the Invention

[0006] Breast cancer therapies have shown limited efficacy in patients with advanced disease making...

Claims

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