Dual phase - PNA conjugates for the delivery of PNA through the blood brain barrier

a technology of pna and conjugates, which is applied in the direction of animal/human proteins, sugar derivatives, non-active ingredients of pharmaceuticals, etc., can solve the problems of limited therapeutic value, the protection function of the blood-brain barrier becomes, and the nutrient transporters in the bbb can only deliver low molecular weight substrates
US20050222009A1Inactive Publication Date: 2005-10-06LAMENSDORF ITSCHAK +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
LAMENSDORF ITSCHAK
Publication Date
2005-10-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides molecule comprising a nucleic acid, a peptide ligand, which binds to a specific receptor and a positively charge peptide moiety with lysosomatic properties, useful in the delivery of a nucleic acid across a cellular membrane. The invention further relates to the use of these compounds for the delivery of a nucleic acid to the brain across the blood brain barrier for diagnostic and therapeutic applications
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Description

CROSS REFERENCE DATA

[0001] This Application claims the priority of U.S. Provisional Application No. 60 / 510,137 filed Oct. 14, 2003.FIELD OF THE INVENTION

[0002] The invention provides compounds comprising a nucleic acid, a peptide ligand which binds to a specific receptor and a positively charge peptide moiety with lysosomatic properties, useful in the delivery of a nucleic acid across a cellular membrane. The invention further relates to the use of these compounds for the delivery of a nucleic acid into the brain for diagnostic and therapeutic applications. BACKGROUND OF THE INVENTION

[0003] The protective function of the blood-brain barrier becomes an important problem in the treatment of neurological diseases. The exclusion of blood-borne foreign substances also results in the exclusion of a large number of potentially therapeutic agents from the brain. The blood brain barrier (BBB) is a very complex endothelial interface separating the brain from the blood compartment and imped...

Claims

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