Methods and devices for termination

Abstract

Devices and methods used in termination of a tissue tightening procedure are described. Termination includes the cinching of a tether to tighten the tissue, locking the tether to maintain tension, and cutting excess tether. In procedures involving anchors secured to the tissue, the tether is coupled to the anchors and the tissue is tightened via tension applied to the anchors by cinching the tether. In general, the devices and methods can be used in minimally invasive surgical procedures, and can be applied through small incisions or intravascularly. A method for tightening tissue by fixedly coupling a first anchor to a tether and slidably coupling a second anchor to the tether, securing both anchors to the tissue, applying tension to the tether intravascularly, fixedly coupling the tether to the second anchor, and cutting the tether is described. The tissue to be tightened can comprise heart tissue, in particular heart valve annulus tissue. Various devices and methods for locking the tether in place and cutting excess tether are described.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of U.S. Ser. No. 11 / 232,190, filed Sep. 20, 2005, which is a continuation-in-part of U.S. Ser. No. 10 / 792,681, filed Mar. 2, 2004, which claims the benefit of U.S. Ser. No. 60 / 459,735, filed on Apr. 1, 2003, U.S. Ser. No. 60 / 462,502, filed on Apr. 10, 2003, and U.S. Ser. No. 60 / 524,922, filed on Nov. 24, 2003, and which is a continuation-in-part of U.S. Ser. No. 10 / 741,130, filed on Dec. 19, 2003, which is a continuation-in-part of U.S. Ser. No. 10 / 656,797, filed on Sep. 4, 2003, and is a continuation-in-part of U.S. Ser. No. 10 / 461,043, filed on Jun. 13, 2003, the latter of which claims the benefit of U.S. Ser. No. 60 / 388,935, filed on Jun. 13, 2002, U.S. Ser. No. 60 / 429,288, filed on Nov. 25, 2002, U.S. Ser. No. 60 / 445,890, filed on Feb. 6, 2003, and U.S. Ser. No. 60 / 462,502, filed on Apr. 10, 2003, the disclosures of which are herein incorporated by reference in their entirety.FIELD [0002] T...

AI Technical Summary

Benefits of technology

[0010] Described herein are devices and methods for use in termination procedures during tissue tightening treatments. In general, termination involves any one or all of the steps carried out when finishing a tissue tightening procedure, including: cinching a tether to tighten tissue; locking the cinching tether in place; and cutting off excess tether. Tissue anchors can be secured to the tissue to be tightened and the tether coupled to the anchors, so that cinching of the tether tightens the tissue via the anchors.

Problems solved by technology

For many minimally invasive surgery techniques, significant challenges include positioning the treatment device or devices in a desired location for performing the procedure and deploying the treatment into or on the target tissue.

In addition, valve repair and replacement is typically technically challenging and requires a substantial incision through a heart wall to access the valve.

Many patients such as elderly patients, children, patients with complicating conditions such as comorbid medical conditions or those having undergone other surgical procedures, and patients with heart failure, are not considered candidates for heart valve surgery because of the high risk involved.

However, during endoscopic surgery, the manipulation required when knotting or tying suture material can be difficult because of severely restricted space.

However, these methods do not provide adjustable tension such as is available when a surgeon uses suture.

Similar crimping devices that operate to mechanically fasten suture together and cut away excess tether are provided as TI-KNOT® knot replacement systems by LSI Solutions.® However, with crimping schemes, the suture may still slip through crimps and lose tension, especially if the suture has a small diameter, if the suture is made of a material susceptible to slippage, such as metal or TEFLON® fluoropolymer, or if the crimp is insufficiently deformed.

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