Method of making, and, analyte sensor

a technology of analyte sensor and electrode, applied in the field of analyte sensor, can solve the problems of unable to use this type of glucose strip construction, unable to control the potential difference between the two electrodes, and the mediator end up dissolved, and achieve the effect of superior performance and superior performance of the ag/agcl counter electrod

Inactive Publication Date: 2007-05-03
ABBOTT DIABETES CARE INC
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  • Summary
  • Abstract
  • Description
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Benefits of technology

[0011] This invention combines the manufacturing advantages of using sputtered metals with the superior performance of the Ag/AgCl counter electrode. This is accomplished by using sputtering to deposit metals and/or a reactive layer for the electrodes, such as a AgCl layer. The methods of making the reactive Ag

Problems solved by technology

However the meter, to which the sensor is connected, may only control the difference in potential between the two electrodes.
Many of the best mediator compounds are not soluble at high concentrations such as 100 mM so they cannot be used for this type of glucose strip construction.
Most of the mediator ends up dissolved in the solution far away from the counter/reference electrode and serves no useful purpose.
Increasing the applied potential however bring the risk of reacting with electrochemically active interferences in the blood and generally results in poorer accuracy of the glucose measurement.
Despite t

Method used

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  • Method of making, and, analyte sensor
  • Method of making, and, analyte sensor
  • Method of making, and, analyte sensor

Examples

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examples

[0126] The following non-limiting examples further illustrate the invention. All parts, percentages, ratios, etc., in the examples are by weight unless otherwise indicated.

[0127] Silver / silver chloride (Ag / AgCl) films were deposited in a sputtering system equipped with a liquid-nitrogen trap, at a rate of 1000 liters / sec, and a cryopump configured to obtain 2.0×10−7 Torr. Two 20 cm diameter×0.64 cm thick, water cooled, targets were used, one 99.97% pure Ag and the second 99.9% pure AgCl. The sputtering was done in 99.999% pure Ar gas, at a flow rate of 20 cm3 / minute at a discharge pressure of 10×10−3 Torr.

[0128] The target configuration for the Ag target was a DC Magnetron, and the AgCl target was a RF diode. The bias voltage during deposition, for the Ag and AgCl was −375 and 1150, respectively. The spacing between the targets and substrate was 6.25 cm. To maximize film uniformity, the grounded annular table was rotated at 2.5 revolutions per minute. Under these conditions, the f...

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Abstract

The subject invention provides conductive stripes, suitable for use as electrodes, and methods of making conductive stripes.

Description

FIELD OF THE INVENTION [0001] This invention relates to analyte sensors. BACKGROUND OF THE INVENTION [0002] Electrochemical analytical sensors are commonly used to determine the presence and concentration of a biological analyte. Such sensors are used, for example, to monitor blood glucose levels in diabetic patients. [0003] The measurement of glucose in blood at home by people with diabetes is important in the management of their disease. The blood glucose is measured using meters and sensors, which are typically thrown away after each use. Various designs of sensors are known. For example, U.S. Pat. Nos. 5,120,420, 5,437,999, 6,143,164, 6,338,790 and 6,616,819 disclose disposable electrochemical sensors with a layered construction having electrodes present on the substrates. [0004] Simplified, the electrochemical glucose strip uses two electrodes to measure the amount of glucose in blood. Additional electrodes may also be incorporated into strip designs. [0005] However, the electr...

Claims

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Application Information

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IPC IPC(8): G01N27/26C23C14/32
CPCC23C14/0694C23C14/205C23C14/3464Y02E60/50H01M4/8885
Inventor WANG, YIHENNING, TIMOTHY P.MARCINIEC, EDMUND T.
Owner ABBOTT DIABETES CARE INC
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