Nasal Delivery Devices

a nasal airway and device technology, applied in the field of nasal airway delivery devices, can solve the problems of not being able to adapt to the delivery of substances to the upper part of the nasal airway, the current nasal airway delivery system can adequately treat topical diseases, and the turbohaler® as developed by astrazeneca ab, etc., to achieve the effect of reducing condensation

Inactive Publication Date: 2008-11-27
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]In another embodiment it is an aim of the present invention to prevent delivery to selected regions of the nasal cavity, in particular to the anterior valve area, by utilizing two separate delivery channels, that is, a central channel for the drug substance and air, and an outer channel which acts to modify and optimize the deposition pattern of the particles in the nasal cavity.
[0007]In one aspect the present invention provides a nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture mitigation means for mitigating an effect of moisture in an ...

Problems solved by technology

Current nasal delivery systems can adequately treat topical diseases, but are not suited to the delivery of substances to the upper part of the nasal airway, and in particular for targeted delivery to the olfactory region and sinus ostia.
The Turbohaler® as developed by AstraZeneca AB, where adapted for nasal delivery has not been...

Method used

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Examples

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second embodiment

[0051]FIGS. 2(a) to (f) illustrate a nasal delivery device in accordance with the present invention.

first embodiment

[0052]The delivery device of this embodiment is very similar to the delivery device of the above-described first embodiment, and thus, in order to avoid unnecessary duplication of description, only the differences will be described in detail.

[0053]The delivery device of this embodiment differs from that of the above-described embodiment in that the nosepiece 53 includes first and second channels 55a, 55b, in this embodiment concentric annular channels, which are centred about the longitudinal axis of the capsule-containing member 49, where the first, inner channel 55a is fluidly connected to the downstream end of the capsule-containing member 49 such that the substance as contained by the capsule C is delivered therethrough and the second, outer channel 55b is fluidly connected by a ducting channel 91 to the mouthpiece 77, in this embodiment upstream of the air chamber 78.

[0054]With this arrangement, a focussed powder aerosol is delivered from the outlet end of the inner channel 55a...

third embodiment

[0055]FIGS. 3(a) to (f) illustrate a nasal delivery device in accordance with the present invention.

[0056]The delivery device comprises a housing 101 which includes a central support spindle 105, a carrier 109 which carries a plurality of substance-containing capsules C, the contents of which are to be delivered to a nasal cavity of the subject, and is movably disposed to the housing 101, in this embodiment rotatably mounted to the housing 101 about the support spindle 105, a nosepiece unit 119 for fitting to a nasal cavity of a subject, a mouthpiece unit 121 through which the subject exhales, and a capsule-piercing mechanism 123, which is operable, in this embodiment simultaneously, to pierce a pair of capsules C and thereby prime the delivery device for operation, as will be described in more detail hereinbelow.

[0057]In this embodiment the capsules C are conventional gelatine capsules which contain a particulate substance, such as a powdered substance, and typically a pharmaceutic...

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Abstract

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pressure-sensitive valve which normally closes the fluid connection between the container chamber and the mouthpiece, and a temperature regulator upstream of the container chamber.

Description

[0001]The present invention relates to nasal delivery devices and methods for delivering substances, in particular particulate substances, such as powdered substances, to the nasal cavities of subjects, and in particular multi-dose devices adapted for use with a plurality of containers, such as capsules, blisters and vials, which each contain a single dose of substance.BACKGROUND OF THE INVENTION[0002]Current nasal delivery systems can adequately treat topical diseases, but are not suited to the delivery of substances to the upper part of the nasal airway, and in particular for targeted delivery to the olfactory region and sinus ostia.[0003]The Turbohaler® as developed by AstraZeneca AB, where adapted for nasal delivery has not been a success. A large fraction of particles is deposited in the anterior region of the nasal cavity. Furthermore, the nasal cavity becomes narrower during nasal inhalation, thus further reducing the deposition efficiency in the posterior regions of the nasa...

Claims

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Application Information

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IPC IPC(8): A61M15/08A61M15/00A61M16/10
CPCA61M15/08A61M2202/064A61M15/0045A61M15/0028A61M16/1075A61M15/0086A61M15/0041A61M15/0035A61M15/0098A61M15/0091A61M16/1055A61M16/1065A61M15/0008A61M15/00A61M11/00A61M15/002A61M15/0021
Inventor DJUPESLAND, PER GISLEHAFNER, RODERICK PETERSHELDRAKE, COLIN DAVID
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