Nucleic Acids For Inhibiting Hairless Protein Expression and Methods of Use Thereof

a technology of hairless protein and nucleic acids, which is applied in the direction of peptide/protein ingredients, drug compositions, genetic material ingredients, etc., can solve the problem that the complete loss of hair, known as atrichia, cannot be treated by the introduction of a new gen

Inactive Publication Date: 2009-01-01
CHRISTIANO ANGELA M
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0037]This invention further provides a method of inhibiting the transition of a hair follicle from the anagen phase to the catagen phase comprising contacting the follicle with an effective amount of the instant nucleic acid molecule or the second pharmaceutical composition.

Problems solved by technology

Lack of expression of the mouse hairless gene due to inherited mutations leads to the complete loss of hair, known as atrichia.
There are, however, conditions—inherited and acquired alike—which cannot be treated by the introduction of a new gene.

Method used

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  • Nucleic Acids For Inhibiting Hairless Protein Expression and Methods of Use Thereof
  • Nucleic Acids For Inhibiting Hairless Protein Expression and Methods of Use Thereof
  • Nucleic Acids For Inhibiting Hairless Protein Expression and Methods of Use Thereof

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Definitions

[0046]As used herein, and unless stated otherwise, each of the following terms shall have the definition set forth below.

[0047]“Administering” shall mean administering according to any of the various methods and delivery systems known to those skilled in the art. The administering can be performed, for example, via implant, transmucosally, transdermally and subcutaneously. In the preferred embodiment, the administering is topical and preferably dermal.

[0048]“Catalytic” shall mean the functioning of an agent as a catalyst, i.e. an agent that increases the rate of a chemical reaction without itself undergoing a permanent structural change.

[0049]“Consensus sequence” shall mean a nucleotide sequence of at least two residues in length between which catalytic nucleic acid cleavage occurs. For example, consensus sequences include “A:C” and “G:U”.

[0050]“Hairless Protein” shall mean the protein encoded by the nucleotide sequence shown in FIGS. 1A-1C (SEQ ID NO:1) and having the am...

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Abstract

The present invention provides DNAzymes and ribozymes that specifically cleave Hairless protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The present invention also provides various methods of inhibiting the expression of Hairless Protein. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes and antisense oligonucleotides as active ingredients.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of copending U.S. patent application Ser. No. 10 / 122,013 filed Apr. 12, 2002, which claims the benefit of priority of U.S. Provisional Application No. 60 / 283,618 filed Apr. 13, 2001, the contents of each of which are hereby incorporated by reference in their entirety.BACKGROUND OF THE INVENTIONThe Hairless Gene[0002]The hairless mouse, a frequent subject of different dermatological experiments, is characterized by hair loss that starts at the age of 14 days postpartum from the upper eyelids and progresses caudally. The process is completed by the age of 3 weeks, when the mice are entirely naked and never grow hair again (Panteleyev et al. 1998b). The phenotype results from proviral integration and consequential aberrant splicing in the mouse hairless gene. Lack of expression of the mouse hairless gene due to inherited mutations leads to the complete loss of hair, known as atrichia. Other mutations have b...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/43C12N9/00C12N15/63C12P19/34C12N15/11A61P17/00A01K67/027A61K9/127A61K31/7088A61K38/00A61K47/10A61K48/00A61P17/14C12N15/09C12N15/113
CPCA61K38/00C12N2310/12C12N15/113A61P17/00A61P17/14
Inventor CHRISTIANO, ANGELA M.
Owner CHRISTIANO ANGELA M
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