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Stent

a technology of stents and stents, which is applied in the field of therapeutic devices, can solve the problems of smc proliferation, stenosis, occluded vessels, etc., and achieve the effects of preventing smc proliferation, preventing smc proliferation, and preventing stent proliferation

Inactive Publication Date: 2009-01-22
ARK THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The present invention is based in part upon the realisation that devices of the type described in EP-A-0730849, may be modified for use at the site of an end-to-end, end-to-side o

Problems solved by technology

When intimal hyperplasia occurs, de novo thickening of the intimal layer, or vessel wall may result, causing the vessel to become stenosed, or occluded.
Surgical anastomoses, in particular with bypass grafts (in which a vein or synthetic substitute is anastomosed to an artery), may result in SMC proliferation and, consequently, stenosis.
When an obstruction in a blood vessel has been cleared, intimal hyperplasia occurring after such intervention may lead to the vessel's becoming occluded again.
A significant number of arterial bypass grafts fail, i.e. become occluded, in the first two years following surgery.
In these cases, it is SMC intimal hyperplasia that often is responsible for causing stenosis of the arterial lumen, eventually resulting in complete occlusion.

Method used

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Embodiment Construction

[0012]A device of the invention preferably comprises an arcuate body portion which, in use, straddles the native vessel, and a tubular body portion which, in use, surrounds an artery, vein or synthetic graft. The arcuate portion may describe up to 2700 or more, depending on flexibility. The tubular portion is typically positioned at about the midpoint of the arcuate portion. The axis of the tubular portion typically defines an acute angle (for example, 15°, 30°, 45° or 60°) with respect to the length of the arcuate portion.

[0013]The term “end-to-side” as used herein refers to an anastomosis in which an end of the (natural or synthetic) graft vessel is grafted onto the side of the native vessel. The term “non-restrictive” as used herein refers to an external stent which allows unrestricted expansion of the graft in initial response to arterial pressure.

[0014]The term “porous” as used herein refers to the ability of the external stent to be invaded by cells and small blood cells, and ...

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Abstract

An elongate device (19), arcuate in cross-section, for placement around a vessel (4), comprises an essentially non-porous outer layer and a biodegradable inner layer. An alternative device comprises a tubular portion (3) for placement around a graft and a portion (2), arcuate in cross-section that can straddle a native vessel, at the site of an end-to-side anastomosis.

Description

FIELD OF THE INVENTION[0001]This invention relates to a therapeutic device, sometimes described herein as an external (vascular) stent, and to its use.BACKGROUND TO THE INVENTION[0002]Neo-intimal hyperplasia represents an increase in the number of smooth muscle cells (SMC's) between the endothelium and the internal elastic lamina of a blood vessel. When intimal hyperplasia occurs, de novo thickening of the intimal layer, or vessel wall may result, causing the vessel to become stenosed, or occluded. Proliferation of arterial SMC's commonly occurs when a blood vessel is deformed, or disturbed during surgery. Surgical anastomoses, in particular with bypass grafts (in which a vein or synthetic substitute is anastomosed to an artery), may result in SMC proliferation and, consequently, stenosis.[0003]When an obstruction in a blood vessel has been cleared, intimal hyperplasia occurring after such intervention may lead to the vessel's becoming occluded again. This is known as re-stenosis an...

Claims

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Application Information

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IPC IPC(8): A61F2/06A61B17/11A61F2/02
CPCA61B17/11A61B2017/1107A61F2210/0004A61F2/064A61F2002/30062A61B2017/1135A61B2017/1132
Inventor BARKER, STEPHEN EDWARD GEORGE
Owner ARK THERAPEUTICS
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