Process for making montelukast and intermediates therefor

a technology of montelukast and intermediates, which is applied in the direction of drug compositions, immunological disorders, organic chemistry, etc., can solve the problems of not being able to provide the compound (2) stereoselectively, and not being able to obtain the racemic produ
US20090093636A1Inactive Publication Date: 2009-04-09BENOVSKY PETR +6
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BENOVSKY PETR
Publication Date
2009-04-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof:using a compound of formula (11)is provided.
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Description

[0001] This application is a Divisional of U.S. patent application Ser. No. 11 / 561,689, filed Nov. 20, 2006, the entire contents of which are incorporated herein by reference, which application claims the benefit of priority under 35 U.S.C. § 119(e) from U.S. provisional patent application Ser. No. 60 / 737,752, filed Nov. 18, 2005; Ser. No. 60 / 794,429, filed Apr. 24, 2006; and Ser. No. 60 / 824,382, filed Sep. 1, 2006, the entire contents of each provisional application being incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] The present invention relates to the synthesis of montelukast, a pharmaceutical agent, as well as to intermediates and processes useful in the synthesis.

[0003] Montelukast, chemically [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropane acetic acid, has the following structure of formula (1):

[0004] Montelukast monosodium salt (montelukast sodium) is commonly used for treatment ...

Claims

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