Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
a technology of biological target molecules and organic molecules, applied in the field of rapid identification of small organic molecule ligands for binding to biological target molecules, can solve the problems of limited combinatorial approaches, limited approaches, and inability to identify, etc., and achieves rapid and efficient identification, easy to perform, and high efficiency.
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[0028]The present invention provides a rapid and efficient method for identifying small organic molecule ligands that are capable of binding to selected sites on biological target molecules of interest. The organic molecule ligands themselves identified by the subject methods find use, for example, as lead compounds for the development of novel therapeutic drugs, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like, or two or more of the identified organic molecule ligands may be coupled together through one or more linker elements to provide novel biomolecule-binding conjugate molecules.
[0029]One embodiment of the subject invention is directed to a method for identifying an organic molecule ligand that binds to a site of interest on a biological target molecule. As an initial step in the herein described method, a biological target molecule is obtained as a target for binding to the small organic molecule ligands scree...
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