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Methods of Inducing and/or Enhancing an Immune Response To Tumor Antigens

a technology of immune response and tumor, which is applied in the field of inducing and/or enhancing immune responses to tumor antigens to achieve the effect of breaking tolerance and enhancing immune response to tumor antigen

Inactive Publication Date: 2010-10-14
SANOFI PASTEUR LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]The present inventors have found that administering the tumor antigen or nucleic acid coding therefor directly into a lymphatic site (such as a lymph node) induces and / or significantly enhances the immune response to the tumor antigen and / or breaks tolerance to the tumor antigen, both which have been a major challenge in previous methods of cancer immunotherapy.

Problems solved by technology

The present inventors have found that administering the tumor antigen or nucleic acid coding therefor directly into a lymphatic site (such as a lymph node) induces and / or significantly enhances the immune response to the tumor antigen and / or breaks tolerance to the tumor antigen, both which have been a major challenge in previous methods of cancer immunotherapy.

Method used

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  • Methods of Inducing and/or Enhancing an Immune Response To Tumor Antigens
  • Methods of Inducing and/or Enhancing an Immune Response To Tumor Antigens
  • Methods of Inducing and/or Enhancing an Immune Response To Tumor Antigens

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0096]This example compares the intranodal injection with subcutaneous injection of a representative tumor antigen (modified gp100).

Methods and Experimental Design

Test System

[0097]Cynomolgus monkeys (Macaca fascicularis) purpose bred animals.

Supplier: Siconbrec “Simian Conservation Breeding & Research Center Inc.”, Fema Building, 44 Gil Puyat Avenue Makati, Metro Manila, Philippines.

[0098]Number of animals in the study: 12 (6 males and 6 females).

Age at initiation of treatment: 26 to 38 months.

[0099]Body weight range at initiation of treatment (day −1):

[0100]males: 1.73 to 2.34 kg

[0101]females: 1.71 to 2.65 kg.

Animal Husbandry

[0102]Housing: one air-conditioned room;

[0103]temperature: 19 to 25° C. (target range),

[0104]relative humidity: >40%

[0105]air changes: minimum 8 air changes per hour,

[0106]lighting cycle: 12 hours light (artificial) / 12 hours dark.

[0107]Caging: animals were housed singly in stainless steel mesh cages (approximately 540×810×760 mm).

[0108]Diet: expanded complete c...

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Abstract

An improved method of inducing and / or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and / or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.

Description

FIELD OF THE INVENTION[0001]The present invention relates to methods for inducing and / or enhancing immune responses to tumor antigens.BACKGROUND OF THE INVENTION[0002]Using immunological approaches to cancer therapy has been difficult as tumor cells are self-derived and therefore not as immunogenic as exogenous agents such as bacteria and viruses. As a result, the prospects of cancer immunotherapy rely upon the identification of tumor associated antigens (“TAA”) which can be recognized by the immune system. Specifically, target antigens eliciting T cell-mediated responses are of critical interest. This comes from evidence that cytotoxic T lymphocytes (CTLs) can induce tumor regression both in animal models (Kast W. et al (1989) Cell 59:6035; Greendberg P. (1991) Adv. Immunol. 49:281) and in humans (Boon T. et al. (1994) Annu. Rev. Immunol. 12:337). To date, many tumor associated antigens have been identified. These include the antigens MAGE, BAGE, GAGE, RAGE, gp100, MART-1 / Melan-A, ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/395A61K31/7052A61K35/76A61K35/74A61K35/00A61P37/04A61K48/00A61K31/7088A61K38/00A61K39/00A61K39/235A61K39/245A61K39/275A61P35/00A61P37/02C07K14/47C07K14/705C12N5/10C12N7/00C12N9/64C12N15/09C12N15/863
CPCA61K39/00A61K39/0011A61K2039/53C07K14/4748C12Y304/24011C12N15/86C12N2710/24043C12N2710/24071C12N9/6494A61P31/14A61P35/00A61P37/02A61P37/04A61K39/001184A61K39/001194A61K39/00117A61K39/001188A61K39/001191A61K39/001106A61K39/001151A61K39/001182A61K39/001156A61K39/001192A61K39/001186A61K39/001195
Inventor BERINSTEIN, NEILTARTAGLIA, JAMESMOINGEON, PHILIPPEBARBER, BRIAN
Owner SANOFI PASTEUR LTD
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