Methods and cosmetic preparations for the sustained delivery of therapeutic agents to the eye

Abstract

Cosmetic compositions comprising therapeutic agents for the treatment of various eye conditions and methods of use are described. In particular, the invention provides cosmetic compositions comprising ophthalmic therapeutic agents in combination with a muscle fasciculating agent for application to the outer surface of the upper eyelid, perimeter of the eyelid and / or eyelashes thereby causing transfer of the therapeutic agents into the vascular network within the eyelid for delivery into all parts of the eye, including the posterior segments of the eye, the eyelid glands, conjuctiva and periocular tissue.

Description

CROSS-REFERENCE OF RELATED APPLICATION

[0001] This application claims priority to Provisional Application Ser. No. 61 / 289,471, filed Dec. 23, 2009 and Provisional Application Ser. No. 61 / 256,614, filed Oct. 30, 2009, both of which are incorporated herein by reference thereto.TECHNICAL FIELD

[0002] The present invention relates generally to cosmetic preparations and their use to deliver therapeutic agents to treat various conditions affecting the eye. More specifically, the present invention relates to methods and compositions for delivery of one or more therapeutic agents to the eye by topical application of a cosmetic composition containing the therapeutic agent(s) to the eyelid, perimeter of the eyelid and / or eyelashes. More specifically, these methods comprise applying a cosmetic preparation containing the desired therapeutic agent or combination of therapeutic agents to the surface of the eyelid, perimeter of the eye and / or eyelashes thereby causing transfer of the therapeutic agent...