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Methods, compositions and apparatuses for facilitating regeneration

a technology of tissue and organ regeneration and composition, applied in the direction of instruments, anti-microbial ingredients, therapy, etc., can solve the problems of stem cell transplant therapy, cell types that are not observed to be replaced, and death in a matter of days, so as to reduce the proportion

Inactive Publication Date: 2011-05-05
SIWA CORP (US)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a way to remove cells that interfere with regenerative processes and promote the growth of stem cells. The invention uses techniques to kill cells based on their degree of functionality, preserving proliferating cells while eliminating partially- or non-functional cells. The technique can involve physical, electromagnetic, chemical, or biological methods, such as ultrasound, antibodies, or toxic nanoparticles. The invention can be used sequentially or simultaneously in combination with other techniques and must avoid excessive inflammatory responses. The evaluation of improvement or maintenance of a desired result can determine the frequency of reapplication of the invention.

Problems solved by technology

In fact, if all stem cells in the body were destroyed, death would follow in a matter of days.
However, in a variety of diseases, malfunctions (such as male pattern baldness) and tissue injuries, cell types are not observed to be replaced when damaged or nonfunctional.
Stem cell transplant therapy is proposed for such conditions, although it is not always successful.

Method used

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  • Methods, compositions and apparatuses for facilitating regeneration

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example 1

[0033]In an embodiment of the present invention glycation end-products, crosslinks created by sugars bonded to proteins, are selected as indicia of an accumulation of cellular damage correlated with partial- or non-functionality. Antibodies against such glycation end-products can be raised according to methods well known to those skilled in the art (e.g. Abed et al., U.S. Pat. No. 6,380,165; Bucala, U.S. Pat. No. 5,702,704) and humanized monoclonal antibodies retaining constant regions which permit destruction of targeted cells by the immune system can be produced for injection, also according to well known methods (e.g. Basi et al., U.S. Pat. No. 7,256,273). Antibodies can be screened for effectiveness according to the present invention by labeling them and applying them separately to untreated cells versus cells incubated with a sugar such as ribose used to induce formation of glycation end-products. Binding of the antibodies to a higher degree to the cells previously incubated wi...

example 2

[0036]In another embodiment of the present invention, glycation end-products, crosslinks created by sugars bonded to proteins, are selected as indicia of an accumulation of cellular damage correlated with partial- or non-functionality. This crosslinking manifests itself in a stiffening of the cells. Those in the art understand stiffness to distinguish types of proliferating versus non-proliferating cells (e.g. Kas et al., U.S. Pat. No. 6,067,859).

[0037]Ultrasound apparatus can be used according to practices well known to those skilled in the art to destroy cells by vibrational techniques (e.g. Chapelon et al., U.S. Pat. No. 5,601,526). Ultrasound parameters (e.g. frequency, power, and pulsation) can be screened for effectiveness in selectively destroying stiffer cells according to the present invention by application to untreated cells versus cells incubated with a sugar such as ribose used to induce formation of glycation end-products. Vibrational versus thermal destruction by ultr...

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Abstract

Apparatuses, compositions and methods for removing cells which interfere with regenerative processes. The apparatuses, compositions and methods selectively kill partially functional and / or non-functional cells versus functional cells while protecting functional proliferative cells to the extent that, upon removal of the killed cells by disintegration or scavenging, functional cells replace the partially- or non-functional cells.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]The present application claims priority to U.S. Provisional Application Ser. No. 61 / 055,846, METHODS, COMPOSITIONS AND APPARATUS FOR FACILITATING REGENERATION, filed on May 23, 2008, and is hereby incorporated in its entirety by reference.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]Not applicable.INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ON A COMPACT DISC[0003]Not applicable.FIELD OF THE INVENTION[0004]The present invention relates in general to methods, compositions and apparatus for promoting tissue and organ regeneration, and in particular to preventing cells from inhibiting regenerative processes to obtain the recognized benefits in health and function associated with the results of regeneration.BACKGROUND OF THE INVENTION[0005]Tissue and organ regeneration research has focused on the need to stimulate regeneration by activating stem cells by soluble factors or treat partially- or non-functional cells to...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N7/00C07K16/00
CPCA61B18/20G01N33/5091A61N7/00A61B18/1815A61B2018/0047A61N5/10A61N7/02A61B18/18A61P43/00A61K47/6843A61K39/39533C07K16/18A61K47/6817C07K2317/21C07K2317/73A61K39/395
Inventor GRUBER, LEWIS S.
Owner SIWA CORP (US)
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