Medical device

Abstract

The present invention provides a peripheral nerve growth conduit for peripheral nerve repair, in particular conduits through which peripheral nerves can grow. The conduit includes poly-ε-caprolactone (PCL). Preferably, the inner (luminal) surface of the conduit comprises pits having a depth of 1-4 μm. Suitably, the conduit may also include poly-lactic acid (PLA). The inner surface of the conduit may have been treated with an alkaline composition. The present invention also provides a method for treating a peripheral nerve damage using a peripheral nerve growth conduit including poly-ε-caprolactone (PCL). The present invention also provides a kit for treating a peripheral nerve damage having a peripheral nerve growth conduit including poly-ε-caprolactone (PCL).

Description

TECHNICAL FIELD OF THE INVENTION[0001]The present invention relates to scaffolds for peripheral nerve repair, in particular to conduits through which peripheral nerves can grow. The present invention is also concerned with methods of making such scaffolds and of their use in the repair or growth of peripheral nerves. Furthermore, the present invention relates to methods of treating such scaffolds to enhance their suitability for use in promoting peripheral nerve repair.BACKGROUND[0002]The peripheral nervous system (PNS) extends outside the central nervous system (CNS) and provides the functions of, amongst other things, bringing sensory information to the CNS and receiving motor commands from the CNS, coordinating body movements and controlling the involuntary muscles. Unlike the central nervous system, the PNS is not protected by bone and is therefore vulnerable to injuries.[0003]Damage to nerves of the PNS can cause significant motor or sensory impairment. In particular, patients ...

AI Technical Summary

Benefits of technology

[0007]Secondly, the present inventors have found that the mechanical properties of the scaffold must be such as to provide a robust and durable connection between the portions of the damaged peripheral nerve that is to be repaired (e.g. between proximal and distal stumps of a severed peripheral nerve), for example without breaking, swelling or collapsing once implanted. At the same time, the scaffold must exhibit sufficient flexibility to withstand handling and surgical implantation, as well as withstand movement experienced when in situ.

[0112]In a further aspect, the present invention provides use of hydroxide to treat the surface of a peripheral nerve growth scaffold including poly-ε-caprolactone (PCL). Suitably the action of the hydroxide encourages growth of peripheral nerves on said surface.

Problems solved by technology

Firstly, the material from which the scaffold is made must be not only biocompatible but also subject to in vivo degradation at a rate which is sufficiently slow to ensure adequate time for the nerve to grow through the defect gap but fast enough to ensure that the scaffold does not remain at the site of the injury such that adequate healing can occur.

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