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Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine

Inactive Publication Date: 2012-12-20
NOVA SOUTHEASTERN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013]The invention provides a composition, including epinephrine nanoparticles, capable of enhancing the sublingual bioavailability of epinephrine, particularly in the emergency treatment of anaphylaxis.

Problems solved by technology

Further, the buccal mucosa has low enzymatic activity relative to the nasal and rectal routes.

Method used

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  • Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
  • Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
  • Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine

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Embodiment Construction

[0029]For the purpose of promoting an understanding of the principles of the invention, reference will now be made to embodiments illustrated herein and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended. Any alterations and further modification in the described compositions and methods and any further application of the principles of the invention as described herein, are contemplated as would normally occur to one skilled in the art to which the invention relates.

Summary of In Vitro Diffusion Experiments and Results

[0030]The experiments described herein were carried out to assess the in vitro diffusion of epinephrine nanoparticles. The use of epinephrine nanoparticles instead of epinephrine salt was hypothesized to enhance the sublingual bioavailability of epinephrine from administration of a fast-disintegrating sublingual tablet formulation for the emergency treatment of anap...

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Abstract

The invention provides a composition including epinephrine nanoparticles and methods for therapeutic use of the composition in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of priority to U.S. Provisional Patent Application No. 61 / 309,136, filed on Mar. 1, 2010, the content of which is hereby incorporated by reference in its entirety.[0002]This application is related to U.S. Provisional Patent Application No. 60 / 715,180, filed on Sep. 9, 2005, and U.S. Provisional Patent Application No. 60 / 759,039, filed on Jan. 17, 2006. This application is also related to U.S. Utility patent application Ser. No. 11 / 672,503, filed on Feb. 7, 2007, now abandoned, which is a continuation-in-part of U.S. Utility patent application Ser. No. 11 / 530,360, filed on Sep. 8, 2006, now abandoned. The aforementioned provisional and utility applications are hereby incorporated by reference in their entireties. The information incorporated is as much a part of the instant application as filed as if the text was repeated in the application, and should be treated (the incorporated information) as part of...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61P37/08A61P11/00A61P9/00A61P11/06B82Y5/00B82Y40/00
CPCA61K9/006A61K9/19A61K31/137A61K9/51A61K9/14A61K9/146A61P9/00A61P11/00A61P11/06A61P37/08
Inventor RAWAS-QALAJI, MUTASEMNIEVES, ENRIQUESIMONS, KEITH JOHNREED SIMONS, FRANCES ESTELLERACHID, OUSAMA
Owner NOVA SOUTHEASTERN UNIVERSITY
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