Method of Using FOXO3A Polymorphisms and Haplotypes to Predict and Promote Healthy Aging and Longevity

a technology of foxo3a and polymorphisms, applied in the field of using foxo3a polymorphisms and haplotypes to predict and promote healthy aging and longevity, can solve the problems of disappointing studies of candidate genes in humans, hereafter referred to as “longevity genes,” and achieve the effect of wide spread of human aging phenotypes and longevity, and maximum coverage of each gen
US20130295566A1Inactive Publication Date: 2013-11-07KUAKINI MEDICAL CENT
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
KUAKINI MEDICAL CENT
Publication Date
2013-11-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides methods and compositions relating to identification and use of genetic information from the FOXO3A gene that can be used for determining and increasing an individual's likelihood of longevity and of retaining physical and cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease, including coronary artery (heart) disease, stroke, cancer, chronic pulmonary disease, diabetes, Parkinson's disease and dementia.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application is in part based on, and claims the benefit of, U.S. Provisional Patent Application No. 61 / 087,722, filed Aug. 10, 2008, which is incorporated herein by reference.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] This invention was made with government support under grant 1 R01 AG027060-01 (Defining the Healthy Aging Phenotype) from the National Institute on Aging. Additional funding was provided by U.S. government support under contract N01-HC-05102 from the National Heart, Lung, and Blood Institute, contract N01-AG-4-2149 and grants 5 U01 AG019349-05 and K08 AG22788-02 from the National Institute on Aging. The U.S. government has certain rights in the invention. Additional support came under grant 2004-0463 from the Hawaii Community Foundation.FIELD OF INVENTION

[0003] The invention relates to a method of using FOXO3A polymorphisms and haplotypes in diagnostics to predict or in planning treatments and in...

Claims

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