Family of Silver (I) Periodate Compounds Having Broad Microbial Properties
a silver iodate and compound family technology, applied in the field of silver iodate compounds, can solve the problems of poor silver release profile, difficult to coat or incorporate silver onto a surface, medical devices or other surfaces, etc., and achieve the effects of reducing the risk of infection, and improving the activity of wound dressings
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example 1
Coating Grade 2 Titanium with Ag5IO6
[0082]Various hydrothermal reaction methods have been developed with the starting component being sodium diperiodatoargentate in distilled water, which was reacted to coat Grade 2 (commercially pure) titanium with Ag5IO6:[0083]1) Titanium cord was placed in the reaction vessel during the formation of sodium diperiodatoargentate.[0084]2) Titanium cord was placed in a concentrated solution of sodium diperiodatoargentate, which was then heated at 80° C.[0085]3) Titanium cord was placed in a concentrated solution of sodium diperiodatoargentate, which was then autoclaved.
[0086]Titanium (Ti) cords coated using all three methods were tested for bacteriostatic longevity using day-to-day transfer corrected zone of inhibition (CZOI) assays against Pseudomonas aeruginosa.
[0087]The longevity of method (1) was 3 days, the longevity of method (2) was 8 days, and the longevity of method (3) was 4 days. The uncoated Ti cords did not generate any zone of inhibit...
example 2
[0091]One or more active agents of the present invention were coated on Tegaderm™, Opsite*, and Tensoplast™, all commercially available wound dressings. Tegaderm™ and Opsite* are film dressings (e.g. acrylate polymers / polyurethane polymers, with an adhesive (e.g. acrylic); Tensoplast™ is a cotton / rayon cloth with an elastic adhesive. They were coated by the following methods:
1. Soaked at room temperature with sodium diperiodatoargentate solution.
2. Soaked at 80° C. with sodium diperiodatoargentate solution.
3. Soaked with water, and then soaked at room temperature with sodium diperiodatoargentate solution.
4. Soaked with water, and then soaked at 80° C. with sodium diperiodaloargentate solution.
5. Same as Method 3, except that 0.9% saline was used for the original soak.
6. Same as Method 4, except that 0.9% saline was used for the original soak.
UV-Vis
[0092]None of the dressings produced signal patterns matching that of sodium diperiodaloargentate, suggesting that they were not releasin...
example 3
[0096]Dressings were coated with Ag5IO6 and then were tested for silver species present (XRD), and bacteriostatic longevity (CZOI) testing.
[0097]Dressings coated in this study were used for the diabetic pig wound healing example.
Dressings Coated
[0098]Source Gauze Sponges—100% cotton
[0099]3 ply dressings—rayon / polyester core with upper and lower HDPE layers
Coating Method
[0100]The fibers were coated during the synthesis of Ag5IO6 from sodium diperiodatoargentate (III) (Method A), during direct Ag5IO6 synthesis (Method B), and by suspending the fibers in an Ag5IO6 slurry (Method C).
Results
[0101]Of the coating methods, the autoclave method was the least effective—the 3 ply dressings did not coat adequately to generate zones of inhibition (only 48 ppm Ag was digested from 1 in2 samples in 5 mL digest), while the zone size dropped with time for the gauze dressing (1095 ppm Ag was digested from 1 in2 samples in 5 mL digest). The remaining three methods all generated dressings with comparab...
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