Replacement mitral valve with annular flap

Abstract

A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity, and an annular flap positioned around an exterior of the expandable frame. In some embodiments, the annular flap can extend outward from the frame and have a collapsed configuration and an expanded configuration.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional App. No. 62 / 000,309 filed May 19, 2014, titled REPLACEMENT MITRAL VALVE WITH ANNULAR FLAP, which is hereby incorporated herein by reference in its entirety and is to be considered a part of this specification.BACKGROUND[0002]1. Field[0003]Certain embodiments disclosed herein relate generally to prostheses for implantation within a lumen or body cavity. In particular, certain embodiments relate to expandable prostheses such as replacement heart valves, such as for the mitral valve, that are configured to atraumatically grasp intralumenal tissue.[0004]2. Background[0005]Human heart valves, which include the aortic, pulmonary, mitral and tricuspid valves, function essentially as one-way valves operating in synchronization with the pumping heart. The valves allow blood to flow downstream, but block blood from flowing upstream. Diseased heart valves exhibit impairments such as narrowing of t...

AI Technical Summary

Benefits of technology

The present disclosure is about a prosthesis that can be used to replace a heart valve. It is designed to be deployed within a body cavity and prevent the flow of fluid around it. It consists of an expandable frame and an annular flap positioned around the frame. The frame can radially expand and contract for deployment within the body cavity. The annular flap is secured to the frame and is positioned to create a barrier to fluid flow outside the frame. This helps prevent leaks and other complications during heart valve replacement surgery. The prosthesis can be delivered using a delivery catheter and can be used to treat paravalvular leakage. Overall, this innovation provides a safer and effective way to replace a heart valve.

Problems solved by technology

Diseased heart valves exhibit impairments such as narrowing of the valve or regurgitation, which inhibit the valves' ability to control blood flow.

Such impairments reduce the heart's blood-pumping efficiency and can be a debilitating and life threatening condition.

For example, valve insufficiency can lead to conditions such as heart hypertrophy and dilation of the ventricle.

However, a problem occurs when blood flows around the valve on the outside of the prosthesis.

For example, in the context of replacement heart valves, paravalvular leakage has proven particularly challenging.

An additional challenge relates to the ability of such prostheses to be secured relative to intralumenal tissue, e.g., tissue within any body lumen or cavity, in an atraumatic manner.

Further challenges arise when trying to controllably deliver and secure such prostheses in a location such as at a native mitral valve.

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