Process for producing gallium-68 through the irradiation of a solution target

Inactive Publication Date: 2016-12-08
ION BEAM APPL
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  • Abstract
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Benefits of technology

[0024]The authors have also found that the overall quantity of 68Ga isotope present in the final solution is more important when the eluted solution is, after elution from the strong cation exchanger, complemented with hydrochloric acid solution. This step allows adjusting the pH of the eluted solution, leading to a more efficient process.
[0025]It is also an object of the present invention to provide a disposable cassette for performing the steps of purification and c

Problems solved by technology

Unfortunately, 68Ge/68Ga generators can only produce small quantities of 68Ga per elution, suffer from limited lifetime and present the risk of contaminating the final preparation with the long-lived parent nuclide 68Ge.
The process involves many time consuming steps, requires expensive hardware including solid targets and specia

Method used

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  • Process for producing gallium-68 through the irradiation of a solution target
  • Process for producing gallium-68 through the irradiation of a solution target
  • Process for producing gallium-68 through the irradiation of a solution target

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[0039]The drawings of the figures are neither drawn to scale nor proportioned. Generally, similar or identical components are denoted by the same reference numerals in the figures.

DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION

[0040]According to a first aspect of the invention, it is provided a process for producing and purifying 68Gallium from a target solution comprising zinc irradiated by an accelerated particle beam. Preferentially the target solution is a target solution comprising 68Zn, and more preferentially a target solution comprising isotopically enriched 68Z. Preferentially, the target solution is irradiated by a proton beam. The present invention is intended to be used preferably with a cyclotron apparatus, which delivers high energy proton beams.

[0041]A flow chart of the process according to the invention is illustrated on FIG. 1. First, a target containing a target solution (10) comprising zinc, preferentially an isotopically enriched zinc-68 solution, is irradia...

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Abstract

The present invention relates to a process for purifying and concentrating 68Ga isotope produced by the irradiation with an accelerated particle beam of a 68Zn target in solution. The process according to the invention allows for the production of pure and concentrated 68Ga isotope in hydrochloric acid solution. The present invention also relates to a disposable cassette suitable to perform the steps of purification and concentration of the process.

Description

TECHNICAL FIELD[0001]The present invention relates generally to the field of radiopharmaceutical production. More particularly, the present invention relates to a process for the production of 68Gallium radioisotope from a suitable solution target irradiated by an accelerated particle beam.[0002]The invention also relates to a disposable cartridge for purifying and concentrating the Gallium-68 produced by the irradiation of a isotopically enriched Zinc solution target by an accelerated particle beam.DESCRIPTION OF RELATED ART[0003]Gallium-68 (68Ga) is of special interest for the production of Ga-radiolabelled compounds used as tracer molecules in positron emission tomography (PET) imaging technique. 68Ga forms stable complexes with chelating agents, like DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) and HBED-CC (N,N′-bis-[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N′-diaceticacid) for example. 68Gallium t...

Claims

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Application Information

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IPC IPC(8): G21G1/00B01J39/18C07B59/00B01J41/12B01J47/00A61K51/08B01J39/04B01J41/04
CPCG21G1/001B01J39/043B01J39/18B01J41/043G21G2001/0021B01J47/00A61K51/088C07B59/008C07B2200/05B01J41/12C22B58/00G21G1/10B01J39/05B01J41/05
Inventor ABRUNHOSA, ANTEROALVES, VITORALVES, FRANCISCO
Owner ION BEAM APPL
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