Vascular closure methods and apparatuses

Abstract

A vascular closure device comprised of a sheath-delivered cincture or noose-like device or knot comprised of suture, wire, or other suitable materials, that is placed on the external surface of a puncture wound, and closed. The vascular closure cincture is delivered by a sheath, and after closing is left resident on the external surface of a tissue puncture wound.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of U.S. application Ser. No. 11 / 508,715, filed Aug. 23, 2006, which claims priority to U.S. provisional application 60 / 711,279, filed Aug. 24, 2005, and is a continuation-in-part of U.S. application Ser. No. 11 / 316,775, filed Dec. 23, 2005, the entireties of which are incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to methods and apparatuses for closing punctures and apertures in human and animal tissue and to methods and apparatuses for inserting such an apparatus into such tissue to perform such closure functions.BACKGROUND[0003]This application is related to U.S. provisional application 60 / 711,279, filed Aug. 25, 2005, and U.S. utility application Ser. No. 11 / 316,775, filed Dec. 23, 2005, each of which is incorporated herein by reference. During angiography and related procedures, catheters are inserted through an incision or puncture in the skin and underlying...

AI Technical Summary

Benefits of technology

The device provides rapid and complete closure of vascular punctures with reduced risk of thrombosis and intimal hyperplasia, allowing for true healing with minimal vascular disruption, and can be adapted for various catheter sizes and puncture holes.

Problems solved by technology

With conventional methods, the rate of post-puncture hemorrhage is high, which causes considerable complications.

Difficulties with these methods include the large number of steps necessary to deploy the needles, capture the suture, withdraw the suture, tie the knot, and cut the suture.

In addition, the hole in the blood vessel is often widened by insertion of the instrument, and the suture remains intravascularly on the endothelial surface, and thus can be a nidus for thrombus or intravascular mural hyperplasia with later spontaneous and catastrophic closure of the vessel.

Disadvantages to these methods are related to the high likelihood of thrombosis associated with the intravascular plug or anchor, and the presence of collagen or other bioabsorbable materials which cause inflammation, activate the clotting cascade, and increase the likelihood of thrombosis, which, in an arterial system, is catastrophic.

For example, U.S. Pat. No. 5,100,422 describes a vascular patch that is sutured to the external surface of the damaged blood vessel and U.S. Pat. No. 5,100,422 describes a vascular patch achieved by instilled adhesives and the device for doing such; however, these are generally impractical for catheter-based methods.

These clip devices are composed of thick semi-rigid material, and can be placed only with a specialized instruments, and because of the rigidity have great potential to injure or cut the blood vessel.

Disadvantages of these clip devices in general include difficulty in retrieving the device if misplaced, excessive manipulation required, the thickness of the clip material which tends to cut or shear the blood vessel, the large forces that must be used to curve the staples and fix the clips, the increased possibility of tearing the blood vessel, and the general lack of control of the forces being applied to the blood vessel.

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