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Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis

a technology of mycobacterium tuberculosis and benzotriazine oxide, which is applied in the direction of antibacterial agents, heterocyclic compound active ingredients, organic chemistry, etc., can solve the problem that the current r&d pipeline for new tuberculosis (tb) drugs is inadequate to address emerging drug-resistant strains

Inactive Publication Date: 2017-08-03
SRI INTERNATIONAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides compounds with a specific structure called BTO, which can be used to treat tuberculosis (TB) infections caused by the bacteria Mycobacterium tuberculosis (Mtb). These compounds have been found to have anti-TB activity and can be used alone or in combination with other anti-TB drugs. The invention also provides methods for making BTO compounds and detecting the results of treatment. The technical effects of this invention include providing new compounds for the treatment of TB infections and methods for detecting the effectiveness of treatment.

Problems solved by technology

The current R&D pipeline for new tuberculosis (TB) drugs is inadequate to address emerging drug-resistant strains.

Method used

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  • Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis
  • Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis
  • Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis

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Embodiment Construction

[0023]The following descriptions of particular embodiments and examples are provided by way of illustration and not by way of limitation. Those skilled in the art will readily recognize a variety of noncritical parameters that could be changed or modified to yield essentially similar results. Unless contraindicated or noted otherwise, in these descriptions and throughout this specification, the terms “a” and “an” mean one or more, the term “or” means and / or and polynucleotide sequences are understood to encompass opposite strands as well as alternative backbones described herein. Furthermore, genuses are recited as shorthand for a recitation of all members of the genus; for example, the recitation of (C1-C3) alkyl is shorthand for a recitation of all C1-C3 alkyls: methyl, ethyl and propyl, including isomers thereof.

[0024]The invention provides compounds of formula I, and subgenera and species thereof, compositions, including formulations and kits, containing such compounds, and meth...

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Abstract

Benzotriazine doxides are disclosed as drugs targeting mycobacterium tuberculosis, including novel compounds of formula I:

Description

[0001]This application is a continuation of Ser. No. 13 / 726,135, filed Dec. 23, 2012; which claims priority to PCT / US12 / 68636, filed, Dec. 7, 2012, which claims priority to U.S. 61 / 567,829 filed Dec. 7, 2011.[0002]This invention was made with government support under NIH Contract No. HHSN266200600011C and NIH Grant No. 1R56AI09081-017 awarded by National Institutes of Health (NIH); the Government has certain rights in this invention.INTRODUCTION[0003]The current R&D pipeline for new tuberculosis (TB) drugs is inadequate to address emerging drug-resistant strains. Accordingly, filling the early drug development pipeline with novel therapies likely to slow additional drug resistance is urgent. Combination chemotherapy has been a standard of care for TB since the 1950s, when it was shown that combining drugs slowed the development of drug resistance, particularly for bactericidal compounds.1 The next major breakthrough in TB treatment was the inclusion of rifampin and pyrazinamide in t...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07D253/10A61K45/06C07D403/04C07D401/12C07D417/04A61K31/541A61K31/5377C07D403/12A61K31/53C07D401/04
CPCC07D253/10A61K31/53A61K45/06C07D403/04C07D401/12C07D417/04A61K31/541A61K31/5377C07D403/12C07D401/04C07D413/04A61P31/06A61P31/10A61K2300/00
Inventor MADRID, PETERCHOPRA, SIDHARTHRYAN, KENNETHKOOLPE, GARY
Owner SRI INTERNATIONAL