New delivery vehicle for therapeutic gases
a technology of gas delivery and gas bottle, which is applied in the direction of nervous disorders, inorganic active ingredients, non-active ingredients of pharmaceuticals, etc., can solve the problems of inability to store gas bottles for patients, and the inability of patients to administer certain classes of drugs by oral administration
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example 1
Preparation of the Buccal Delivery Dosage Form
[0059]A buccal delivery dosage form is prepared by heating the excipient, the isomalt, to a temperature of about 330-338° C. for the isomalt to melt and turn liquid. Then inject into the mixture under agitation pressurized Argon, the therapeutic gas, about 600 pounds per square inch; or approx. 41.37 Bar and allow the isomalt / gas mixture to cool down, whereby Argon is entrapped with the re-crystalized isomalt. The process causes tiny high pressure bubbles to be trapped inside the re-crystallized isomalt. The dosage form is then broken down and sieved to the desired size (from 1 to 5 mm), and bagged into 2 grams doses.
example ii
Absorbed Argon for Reducing Stress / Anxiety
[0060]Bags of 2 grams of the Argon-containing buccal delivery dosage form as prepared in Example 1 were handed out to volunteers for testing. The cohort consisted of 8 healthy volunteers between the age of 15 and 60 years old. To better access the effect and absorption of Argon, the experiment was repeated on the same volunteers with a buccal delivery dosage form containing carbon dioxide only.
Protocol:
[0061]Before any uptake, each volunteer was asked to evaluate is stress level on a scale from 1 to 10 (1 is near a meditative state and 10 is the maximum stress and anxiety). This value is the control value.[0062]Then 2 g was taken orally (avoiding swallowing); wait 5 minutes after complete melting and re-evaluation the level of stress / anxiety.[0063]After 5 minutes, take a second 2 g of the buccal delivery dosage form and re-evaluate the level of stress / anxiety.
[0064]The volunteers repeated the protocol 3 times on different days for the CO2-co...
example iii
Effect of Absorbed Argon or CO2 on the Heart Beat Rate
[0067]The same protocol as used in Example II was used in this example. The heart beat rate was measured after 2 g and after 4 g of the buccal delivery dosage form (representing about 2.76 and 5.52 ml of gas, respectively) as prepared in Example 1 was orally taken.
[0068]Each volunteer repeated the protocol 3 times on different days for each one of the CO2-containing dosage form and the Argon-containing dosage form.
[0069]These results as illustrated in FIG. 2 show that the Argon was released and absorbed through the buccal mucosa into the body of the volunteers. The absorption of 2 to 4 g of trapped Argon in a crystallized isomalt did reduce significantly the heart beat rate by 3-6 bpm in average (4-8%, see FIG. 2). It is worthy to note that the CO2-containing dosage form did not cause a reduction of the heart beat rate. In fact, the effect of the CO2 is about equal to the effect of the control, as if no gas was being administered...
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Abstract
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