Compositions and methods for treating wounds

a technology for wounds and compositions, applied in the field of superficial wounds, lesions and sores, can solve the problems of tissue damage, prolong the inflammatory phase, and compromise the immune system of wounds, and achieve the effects of improving the efficacy of the entire mixture, reducing the chance of scarring, and reducing the risk of infection

Inactive Publication Date: 2018-08-09
RED SWAN LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012]Further, in still another particular embodiment, the combined effect of these active ingredients expresses in a synergistic effect, where the co-existence and activity of the active ingredients improve the efficacy of the entire mixture in treating, ameliorating, rehabilitating and / or expediting recuperation from superficial and deep wounds, lesions and / or sores.
[0013]Furthermore, the compositions of the present invention effectively improve chances of regeneration of healthy tissue without scarring or at least with minimal scarring even in deep cuts and in particular intentionally made cuts made in surgical procedures.

Problems solved by technology

It is a necessary part of healing but can lead to tissue damage if it lasts too long.
A wound compromises the immune system.
If, the system is unable to clear the debris from the wound, dead tissue, or microbial biofilm from the wound, then these factors may prolong the inflammatory phase and prevent the wound from properly complete the proliferation phase of healing.
This in turn can lead to a chronic wound.
Injuries are mostly treated with antibiotic formulations to prevent infection, but carry negative side-effects such as breeding bacterial resistance and causing contact dermatitis.
Both antibiotic formulations and currently available natural ointments do not provide a comprehensive solution for different types of wounds, superficial or deep, unintentional or deliberate for example cuts made during surgery.
Further, scarring which is part of the healing process of a wound is almost always inevitable at the wound site.

Method used

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  • Compositions and methods for treating wounds
  • Compositions and methods for treating wounds
  • Compositions and methods for treating wounds

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0052]Exemplary compositions of the invention is prepared by mixing the following core active ingredients: (1) Calendula infused in olive oil, (2) Achillea Millefolium tincture in alcohol, (3) Syzygium Aromaticum floral water extract, and (4) Helichrysum essential oil, as well as (5) raw honeybee honey. In different variants of the composition, the relative weight amount of Calendula infused in oil to the total weight of the composition has been found to be effective in the range between 10% (w / w) and 20% (w / w). In different variants of the composition, the relative weight amount of Achillea Millefolium tincture to the total weight of the composition has been found to be effective in the range between 4% (w / w) to 25% (w / w). In different variants of the composition, the relative weight amount of Syzygium Aromaticum floral water to the total weight of the composition has been found to be effective in the range between 4% (w / w) to 25% (w / w). In different variants of the composition, th...

example 2

[0053]Reference is now made to FIG. 1A to 5C, showing incisions performed on an eight years old female patient, in chest and groin areas. The incision in the chest area hasn't been specially treated and served as a negative control, whereas the incision in the groin area has been intensively treated for a month as well as occasionally throughout the following three to four months, following the incision. The freshly sutured incision in the chest area is shown in FIG. 1A; whereas freshly sutured incision in the groin area is shown in FIG. 1B.

[0054]The incision in the groin area has been treated three to four times throughout each day, for a month, by topical application essentially covering the the entire incision, as shown in FIG. 2, by the composition prepared essentially as set forth in Example 1 supra. After approximately a month, both incisions have closed and a wound tissue was formed, as shown in FIG. 3A and FIG. 3B, respectively.

[0055]The incision in the groin area has receiv...

example 3

[0057]Referring now to FIG. 6A to 7B, where the initial state of a deep severely infected wound inflicted to a middle finger of a male patient, born on 26 Nov. 1956, as well as the final scar tissue of the wound treated by a composition of the invention are shown. The patient has commenced receiving the treatment by a composition of the invention, after the conventional gold-standard medical treatment has failed and the deeply wound and severely infected middle finger of the patient, shown in FIGS. 6A and 6B taken on 25 Dec. 2015, was at a considerably increasing risk of progressing gangrene which would require amputation of the entire middle finger.

[0058]Prior to receiving the treatment by a composition of the invention, the patient has undergone surgical suturing as well as iterative clinical debridement of the wound, as a part of the conventional gold-standard medical treatment received in a modern hospital Ichilov Hospital with contemporary equipment in Tel Aviv, Israel. The pat...

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Abstract

Methods and compositions for treating wounds are described. The compositions include core active ingredients derived from the genera of: Calendula, Achillea Millefolium, Syzygium Aromaticum and Helichrysum. The methods include mixing the core active ingredients, preferably with other secondary active ingredients, adjuvants or excipients, to form the composition and administering the composition by topically applying an effective amount of the composition onto a wound or incision of a patient.

Description

TECHNICAL FIELD[0001]The present invention generally relates to the treatment of superficial wounds, lesions and sores. More particularly, the present invention pertains to compositions and methods for treating, ameliorating, rehabilitating and / or expediting recuperation from superficial and deep wounds, lesions, sores as well as effectively reducing the amount of scar tissue resulting recuperation, thus contributing to an enhanced visual aesthetic effect of the rehabilitated tissue.BACKGROUND ART[0002]Wound healing is an intricate process where the skin or other body tissue repairs itself after injury. The healing process is divided into predictable phases: blood clotting (hemostasis), inflammation, the growth of new tissue (proliferation), and the remodeling of tissue (maturation). In normal skin, the epidermis (surface layer) and dermis (deeper layer) form a protective barrier against the external environment. When the barrier is broken, an orchestrated cascade of biochemical eve...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/28A61P43/00A61K9/00A61K47/44A61K47/10A61K36/61A61K35/644A61K9/06A61K36/30A61K36/185A61K36/53A61K36/752A61K36/537A61K36/54A61K31/07A61K31/355A61K36/71A61K36/23A61K36/738A61K36/899A61K36/67A61K36/85A61K45/06
CPCA61K36/28A61P43/00A61K9/0014A61K47/44A61K47/10A61K36/61A61K35/644A61K9/06A61K36/30A61K36/185A61K36/53A61K36/752A61K36/537A61K36/54A61K31/07A61K31/355A61K36/71A61K36/23A61K36/738A61K36/899A61K36/67A61K36/85A61K45/06A61P17/02A61K2300/00
Inventor BEN-LULU, ORLYALGRESSI, EFRAT
Owner RED SWAN LTD
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