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Platinum complexes and uses thereof

a technology of platinum complexes and complexes, applied in the field of platinum complexes, can solve the problems of limited broader application of platinum-based drugs such as cisplatin and oxaliplatin, short half-life, and substantial risk of severe toxicities

Inactive Publication Date: 2019-08-01
L E A F HLDG GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes a composition that includes a therapeutic agent complexed with a platinum-based drug and a polyglutamate molecule. The composition can be in the form of a liposome, which is a delivery vehicle that can encapsulate the therapeutic agent complex. The therapeutic agent can be cisplatin or an oxaliplatin. The composition can be used to treat hyperproliferative diseases such as cancer. The technical effect of this invention is to provide a more effective and targeted treatment for cancer with reduced side effects.

Problems solved by technology

Despite the pervasiveness of platinum drugs in cancer treatment regimens, broader application of platinum-based drugs such as cisplatin and oxaliplatin is ultimately limited by their low solubility, short half-life, and the substantial risk of severe toxicities, including neurotoxicity.

Method used

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  • Platinum complexes and uses thereof
  • Platinum complexes and uses thereof
  • Platinum complexes and uses thereof

Examples

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example 1

Alpha Polyglutamated Pemetrexed Compositions

[0449]Methods:

[0450]Production of Polyglutamate—Cisplatin Complexes

[0451]To produce polyglutamate—Diammine dicarboxylic acid platinum (DDAP) Complex), an alpha hexaglutamate and Diammine dicarboxylic acid platinum (DDAP) was used. The process of complexation is dependent on the presence of Chlorinated platinum compound and pH conditions. The complexation is achieved by a nucleophilic attack on one or two carboxyl groups of glutamate by the platinate derivative. Briefly the complex was formed by the following procedure. First, the active compound DDAP was weighed and dissolved in 5% dextrose. After the DDAP dissolution step, aG6 is weighed out and added to the DDAP solution and allowed to stir for 1 hour at 37° C. The pH of the solution is adjusted to 6.5-7.0 using 1N NaOH and the solution was stirred overnight at 37° C. The formation of complex was confirmed visually. However when the pH was adjusted to acidic pH (3-4). The color reverted ...

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Abstract

The disclosure generally relates to compositions comprising therapeutic agent complexes and to methods of making and using the compositions. In particular embodiments, the disclosure provides compositions comprising platinum-based drug complexes and to methods of making and using these compositions.

Description

BACKGROUND[0001]Platinum-based compounds are among the most widely used drug classes in cancer therapy. Almost half of the chemotherapy regimens contain a platinum drug. The widespread use of platinum agents in the treatment of cancer began with the discovery of the antineoplastic activity of cisplatin in the 1960s. Despite the pervasiveness of platinum drugs in cancer treatment regimens, broader application of platinum-based drugs such as cisplatin and oxaliplatin is ultimately limited by their low solubility, short half-life, and the substantial risk of severe toxicities, including neurotoxicity. Improvement of drug targeting and delivery systems are effective approaches to mitigate these disadvantages.[0002]There is, therefore, a great need for developing platinum-based drug targeting and delivery systems that are capable preferentially delivering cytotoxic platinum drug-based payloads that have wider therapeutic indices and more favorable toxicity profiles than currently adminis...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/127A61K31/555A61K47/40A61K47/42A61K47/26A61K47/69A61K47/68A61P35/00
CPCA61K9/1271A61K31/555A61K47/40A61K47/42A61K47/26A61K47/6911A61K47/6803A61K47/6849A61P35/00A61K47/645A61K47/6951A61K33/243
Inventor NIYIKIZA, CLETMOYO, VICTOR M.
Owner L E A F HLDG GRP