Measuring time to fusion as a means of determining degree of parallel activation of the heart

a technology of parallel activation and measuring time, which is applied in the direction of angiography, therapy, artificial respiration, etc., can solve the problems of not all patients benefiting from such therapy, patients may experience deterioration, and morbidity

Pending Publication Date: 2022-07-28
PACERTOOL AS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

CRT is associated with a reduction in mortality and morbidity, however, not all patients benefit from such therapy.
In fact, some patients may experience deterioration after treatment, some experience devastating complications, and some experience both.

Method used

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  • Measuring time to fusion as a means of determining degree of parallel activation of the heart
  • Measuring time to fusion as a means of determining degree of parallel activation of the heart
  • Measuring time to fusion as a means of determining degree of parallel activation of the heart

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[0359]The systems and methods described herein may be used both before and during treatment of patients with presumably dyssynchronous heart failure, with a resynchronization pacemaker (CRT) in order 1) identify the presence of an underlying substrate that identifies patients that are likely to respond positively (manifest resynchronization potential present) to and 2) identify optimal locations for placement of pacing leads / electrodes.

[0360]Patients are currently referred for implantation of a CRT pacemaker based on international guidelines that describe indication criteria. These criteria are based on inclusion criteria in larger clinical trials and, amongst other things, consists of symptoms of heart failure, reduced ejection fraction (heart function) and a widened QRS complex (preferably left bundle branch block) beyond 120-150 ms. However, currently only 50-70% of patients with one or more indications for treatment with a CRT actually respond to treatment. Reasons for these non...

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Abstract

A method for determining the degree of parallel activation of a heart undergoing pacing includes calculating vectorcardiogram (VCG), or electrocardiogram (ECG), or electrogram (EGM) waveforms from right ventricular pacing (RVp) and left ventricular pacing (LVp). A synthetic biventricular pacing (BIVP) waveform is generated by summing the VCG of the RVp and LVp, or by summing the ECG of the RVp and the LVp, or by summing the EGM of the RVp and the LVp. A corresponding EGM or ECG or VCG waveform from real BIVP is calculated. The method includes comparing the synthetic BIVP waveform and the real BIVP waveform and calculating time to fusion by determining the point in time in which the activation from RVp and LVp meets and the synthetic and the real BIVP curves start to deviate. A delay in time to fusion indicates a higher degree of parallel activation.

Description

TECHNICAL FIELD[0001]The present invention is concerned with a method and system for measuring time to fusion as a means of determining degree of parallel activation of the heart. Thus, the invention may be used in relation to patients undergoing pacing, and more specifically can apply to the identification of the degree of parallel activation of a paced heart. A delay in time to fusion indicates that a larger amount of tissue is activated before wave fronts for electrical activation meet, thereby indicating a higher degree of parallel activation, and to what extent the pacing of a heart results in effective resynchronisation.BACKGROUND OF THE INVENTION[0002]Cardiac resynchronization therapy (CRT) is consistently provided according to recognized medical standards and guidelines provided by international medical societies in order to treat patients suffering from various conditions such as a widened QRS complex, (left or right) bundle branch block and heart failure. There are some mi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/0215A61N1/368A61B5/0538A61B5/055A61B5/327A61B5/341A61B5/343A61B5/349A61B5/367A61B5/00A61N1/36A61N1/362
CPCA61B5/0215A61B2034/105A61N1/36842A61B5/0538A61B5/055A61B5/327A61B5/341A61B5/343A61B5/349A61B5/367A61B5/7425A61N1/36128A61N1/3622A61N1/3627A61N1/36843A61N1/3686A61N1/36507A61B2562/0219A61B5/316
Inventor ODLAND, HANS HENRIK
Owner PACERTOOL AS
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