Targeted delivery of active/bioactive and perfuming compositions

a technology of active/bioactive and perfuming composition, which is applied in the direction of perfume formulations, instruments, hair cosmetics, etc., can solve the problem of not being able to engineered coordination of the utilization of variables concerned, and achieve the effect of low cos

Inactive Publication Date: 2003-11-11
INTERNATIONAL FLAVORS & FRAGRANCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The system shown in FIGS. 10A and 10B has as its primary purpose the simultaneous evaluation of an air freshener's performance for its hedonics, intensity, volatile content and weight loss as a function of time in a controlled environment of temperature and air mixing. The fragrance diffusion evaluation system is a midway station between

Problems solved by technology

However, no engineered coordination of the utilization of the variables concerned has been shown in the prior art whereby, depending on the changing (as a function of time) physical and chemical properties of the surface treated and surrounding environment, the chemical and physical nature of the active and bioactive product (including diffusivities taken alone and in combination with one another in various

Method used

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  • Targeted delivery of active/bioactive and perfuming compositions
  • Targeted delivery of active/bioactive and perfuming compositions
  • Targeted delivery of active/bioactive and perfuming compositions

Examples

Experimental program
Comparison scheme
Effect test

example i

Preparation of Microparticles Using Silverson L4R Laboratory Mixer of FIG. 11G

The following procedure is used for the preparation of microparticles with the fragrance of Example A and candelilla wax using a Silverson L4R laboratory mixer as set forth in FIG. 11G and described, supra. The resulting formulation is:

74.0% water;

15% candelilla wax;

10% fragrance of Example A; and

1.0% cetyl trimethyl ammonium chloride having the structure: ##STR36##

(1) 37.5 Grams of candelilla wax is placed in an oven at 125.degree. C. and allowed to melt.

(2) 314.87 Grams of deionized water is placed into a steam jacket in a one gallon tank.

(3) The bottom of the tank is piped into the suction side of a Silverson in-line model L4R laboratory rotor / stator mixer. The discharge of the mixer was piped back into the tank to allow for recirculation.

(4) The mixer is turned on slowly and the water is drawn into the mixer and pumped back into the tank.

(5) 3.88 Grams of 29% cetyl trimethyl ammonium chloride solution ...

example ii

Use of Shampoo / conditioner

0.98 Grams of the slurry of Example I containing:

15% candelilla wax;

10% fragrance of Example A; and

1.0% cetyl trimethyl ammonium chloride

is admixed in a Vortex mixer with 14 grams of a non-fragranced shampoo composition, as described in U.S. Pat. No. 5,658,868 issued on Aug. 19, 1997, incorporated by reference herein and containing:

5% (weight) 2-decenyl sulfonate;

15% (weight) sodium sulfosuccinate ester of n-decanolamide;

25% (weight) lauroamphocarboxyglycinate;

4% (weight) coconut amide;

3% (weight) glycol distearate;

4% (weight) aloe vera;

1% (weight) wheat germ oil; and

43% (weight) water.

The resultant mixture is applied to hair in a washing procedure and has an effective fragrance level of 0.6%. The hair is left to dry. After 36 hours, the dried hair thus washed has an aesthetically pleasing aroma having:

(1) a substantivity of 9 on a scale of 1-10;

(2) a quality of 10 on a scale of 1-10; and

(3) an intensity of 6 on a scale of 1-10.

Furthermore, the product prod...

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Abstract

Described are controlled, time-release microparticulate active and bioactive compositions (including perfuming compositions) for targeted delivery to surfaces such as skin, hair and fabric and the environment proximate thereto, where the active and bioactive materials have a calculated log10P values of between 1 and 8 (P being the n-octanol-water partition coefficient). Such compositions include the active or bioactive material in single phase, solid solution in a wax or polymer matrix also having coated thereon and/or containing a compatible surfactant. Also described are processes and apparatus for preparing such compositions and processes for using same. Furthermore, certain component(s) of the aforementioned compositions in combination with one another are novel, and other components have novel uses in increasing fragrance substantivity, particularly in hair care preparations such as hair gels and shampoos.

Description

Our invention relates to controlled time-release microparticulate active and bioactive compositions (including perfuming compositions) for targeted delivery to surfaces such as skin, hair and fabric and the environment proximate thereto. The active and bioactive materials contained in the microparticulate compositions of our invention have a calculated log.sub.10 P of between 1 and 8 (P being the n-octanol-water partition coefficient of the active and bioactive materials). Such compositions include the active or bioactive material in single phase solid solution in a wax or polymer matrix also having coated thereon and / or containing a compatible surfactant. Certain combinations of surfactants useful in the practice of our invention are novel, for the surfactants include partially hydrolyzed polyvinyl acetate. Other materials, to wit: tetra(2-hydroxypropyl)ethylenediamine having the structure: ##STR1##is not only useful as a surfactant, but also increases the substantivity of fragranc...

Claims

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Application Information

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IPC IPC(8): G01N30/00A61K8/11A61Q13/00
CPCA61K8/11A61Q13/00G01N30/00A61K2800/412
Inventor SHEFER, ADISHEFER, SHMUEL DAVID
Owner INTERNATIONAL FLAVORS & FRAGRANCES
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