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YKL-40 as a general marker for non-specific disease

a general marker and non-specific technology, applied in the field of ykl40 as a general marker for non-specific disease, can solve the problems that the serum crp level cannot be used as a sickness-index, and the use of sedimentation rate in asymptomatic persons is limited by its low sensitivity and specificity

Inactive Publication Date: 2014-04-15
HERLEV HOSPITAL +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

YKL-40 provides a more sensitive and specific indicator of non-specific diseases or disorders, allowing for early detection and monitoring of disease severity, even in asymptomatic individuals, and can be used in conjunction with other biomarkers for comprehensive diagnosis.

Problems solved by technology

The usefulness of the sedimentation rate in asymptomatic persons is however limited by its low sensitivity and specificity, but it has been used as a sort of sickness index, when a moderate suspicion of disease was present.
However not all patients with these diseases have an elevated serum CRP level, and for these patients the serum CRP level cannot be used as a sickness-index.

Method used

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  • YKL-40 as a general marker for non-specific disease
  • YKL-40 as a general marker for non-specific disease
  • YKL-40 as a general marker for non-specific disease

Examples

Experimental program
Comparison scheme
Effect test

example 1

Plasma YKL-40 Levels in Normal Subjects and Plasma YKL-40 as an Independent Risk Factor

Methods

Participants

[0190]We used a population-based prospective study of the Danish general population, the 1991-1994 examination of the Copenhagen City Heart Study (Bojesen et al, 2003; Nordestgaard et al, 2007; Schnohr et al, 2002). Participants aged 20 years and above were selected randomly after gender and age stratification into 5-year groups among residents of Copenhagen. Of the 17180 subjects invited, 10135 participated, and plasma was available for YKL-40 determination in 8899 participants. Participants were followed for 16 years using their unique Central Person Registry number from baseline at the 1991-1994 examination until July 2007. Follow-up was 100% complete. Roughly 99% were Caucasians of Danish descent. At time of blood sampling (1991-1994), 1763 participants had a disease known to be associated with increased levels of plasma YKL-40 (cancer, ischaemic cardiovascular disease, live...

example 2

Diurnal, Weekly and Long Time Variation in Serum Concentrations of YKL-40 in Healthy Subjects

Materials and Methods

Reference Interval

[0219]Serum was collected from 245 healthy subjects (women / men 134 / 111, median age 49 years, range 18-79).

Diurnal Variation

[0220]Serum was collected seven times during a 24 hour period (day 1: 10 AM, 1 PM, 4 PM, 7 PM, 10 PM; day 2: 7 AM, 10 AM) from 16 healthy subjects (10 / 6, 48 years, range 32-66).

Day-to-Day Variation over 3 Weeks

[0221]Serum was collected at 8 AM five times during a 3 week period (day 1, 2, 8, 15, and 22) from 38 subjects recruited from the hospital staff (21 / 17, 41 years, range 22-66). At day 8 samples were also collected at 2 PM.

Week-to-Week Variation Over 2 Years

[0222]Serum was collected from 23 subjects recruited from the hospital staff (14 / 9, 42 years, range 31-66) at 8 AM five times during a 3 week period (day 1, 2, 8, 15, and 22) and repeated 6, 12 and 24 months later.

Variation Over 3 Years

[0223]Serum was collected between 8 AM ...

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Abstract

The present invention relates to methods of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the presence of a non-specific disease or disorder. The subject may suffer from a variety of diseases or disorders. The reference level may be a reference level obtained from healthy individuals or it may be a previous measurement obtained from the same subject. The present invention furthermore relates to a method for classifying the severity of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above or below one or more reference levels gives the severity of said non-specific disease or disorder. The present invention further relates to a kit and a device that may be used in the method of the present invention comprising means for measuring the level of YKL-40 in a sample; and means for comparing the measured level of YKL-40 with at least one reference level of YKL-40.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is the U.S. national stage filing under 35 U.S.C. §371 of International Application No. PCT / DK2009 / 050014, filed on Jan. 22, 2009, which claims benefit of Danish Patent Application No. PA 2008 00089, filed on Jan. 23, 2008, Danish Patent Application No. PA 2008 01292, filed on Sep. 15, 2008, Danish Patent Application No. PA 2008 01293, filed on Sep. 15, 2008, and Danish Patent Application No. PA 2008 01294, filed on Sep. 15, 2008, each of which is incorporated by reference.FIELD OF INVENTION[0002]The present invention relates to a method of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the presence of a non-specific disease or disorder. The subject may suffer from a variety of diseases or disorders. The present invention furthermore relates to a method for classifying the severity of a non-specific disease or disorder in a...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): C12Q1/37
CPCG01N2400/00G01N33/6893G01N2800/50
Inventor JOHANSEN, JULIABOJESEN, STIGNORDESTGAARD, BORGE GRONNENIELSEN, HANS JORGENCHRISTENSEN, IB JARLE
Owner HERLEV HOSPITAL