The invention discloses multifunctional amino acid cleansing cream which is prepared from the following raw materials in percentage by weight: 20-25% of glycerol, 7.5-22.5% of an amino acid surfactant, 5-15% of 1,3-propylene glycol, 0.1-0.3% of xanthan gum, 0.5-0.1% of EDTA disodium, 1-2% of lauryl glucoside, 0.01-0.02% of an acne removing component, 1-6% of grease, 0.01-0.05% of sodium hyaluronate, 0.005-0.01% of sodium polyacrylate, 2-3% of a plant anti-allergic agent, 0.1-0.3% of a plant preservative, 0.1-0.2% of essence and the balance of deionized water, wherein the amino acid surfactantcomprises sodium myristoyl glutamate, sodium cocoyl glutamate and sodium lauroyl glutamate. Under cooperative effect of each raw materials, the cleaning cream provided by the invention can safely andeffectively remove heavy makeup of eyes and lips, is mild and free of stimulation, is moist mildand is not moist, can effectively remove acnes and a few pimples, improves sensitive skin, reduces an allergy rate, can prolong essence smell and effectively covers peculiar smell. The invention further discloses a preparation method for the multifunctional amino acid cleansing cream.