The invention discloses an internet of things-based man-machine interactive plotting system and operation method thereof, and belongs to the technical field of plotting. The internet of things-based man-machine interactive plotting system comprises a plurality of plotting terminal devices, wherein one plotting terminal device is a primary device and the other plotting terminal devices are secondary devices; and each plotting terminal device comprises a glass plate desktop, an interactive intelligent panel, a baffle plate, a projection device, a camera device, an LED illumination device, a pullrod, a rotation shaft, a lower base, an upper bracket, a fastening knob, a transverse guiderail, a longitudinal guiderail, an overturn bracket and a keyboard-mouse integrated function plate. According to the system, image information is output and acquired through optical means, and design tasks are summarized and distributed through a network technology. The system realizes practicability in various jobs by taking man-machine engineering as guidance. For example, plotting tasks are distributed in teaching and plotting levels are uniformly assessed; in the design field, design teams are overall planned and design schemes are interactively discussed; and in the field of cartoon and art, sketches are cut to e completed by multiple users.