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38 results about "HIF prolyl-hydroxylase inhibitor" patented technology
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Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) also known as Hypoxia-Inducible Factor stabilizers (HIF stabilizers) are members of a class of new drugs that act by inhibiting prolyl hydroxylase which is responsible to break down the hypoxia-inducible factor (HIF) under normoxic conditions.
Substituted 4-Hydroxypyrimidine-5-Carboxamides
ActiveUS20090239876A1Increase productionReduce productionBiocideOrganic chemistryProlyl HydroxylasesHif prolyl hydroxylase
The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Isoquinolone compound and application thereof
The invention relates to an isoquinolone compound and application thereof. The invention in particular relates to an isoquinolone compound used as a HIF prolyl hydroxylase inhibitor (HIF-PHI) and a pharmaceutical composition thereof. Moreover, the present invention provides the application of the isoquinolinone compound or the pharmaceutical composition thereof in the preparation of a medicament for preventing or treating HIF-associated or HIF-mediated diseases as anemia or ischemia, local ischemia or hypoxia.
Owner:SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD
Compositions and methods for treating anemia
PendingUS20160143891A1Raise serum hemoglobinRiskHeavy metal active ingredientsBiocideDosing regimenNephrosis
Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.
Owner:AKEBIA THERAPEUTICS
Compositions and Methods for Treating Anemia
ActiveUS20180092892A1Reduced average total daily doseOrganic chemistryAmide active ingredientsRegimenNon dialysis dependent
Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia secondary to or associated with non-dialysis dependent chronic kidney disease anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.
Owner:AKEBIA THERAPEUTICS
Spiroindalones
ActiveUS20100137297A1Increase productionReduce productionBiocideOrganic chemistryHif prolyl hydroxylaseProlyl Hydroxylases
The present invention relates to spiroindalone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Spiroazaindoles
ActiveUS20110152304A1Increased endogenous productionReduced endogenous productionBiocideOrganic chemistryProlyl HydroxylasesHif prolyl hydroxylase
The present invention relates to spiroazaindole compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Novel 1,8-naphthyridine compounds
The present invention relates to naphthyridine compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK & CO INC
Novel 1.8-naphthyridine compounds
InactiveUS20100056563A1Increased endogenous productionReduced endogenous productionBiocideOrganic chemistryProlyl HydroxylasesHif prolyl hydroxylase
The present invention relates to naphthyridine compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME CORP
Tetrahydrofuropyridones
The present invention relates to Tetrahydrofuropyridones compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Substituted pyrimidines
The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:BIODURO BAONUO TECH BEIJING CO LTD +1
Substituted pyrimidines
The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC +2
Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones
InactiveCN102459278AEnhance endogenous productionReduce anemiaOrganic chemistryMetabolism disorderHif prolyl hydroxylaseProlyl Hydroxylases
The present invention relates to substituted 1,3,8-triazaspiro[4.5]decame-2,4-diones useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
![Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones](https://images-eureka.patsnap.com/patent_img/431918bd-efbe-4456-b96e-9f1772f393f6/117202DEST_PATH_IMAGE071.PNG "Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones")
![Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones](https://images-eureka.patsnap.com/patent_img/431918bd-efbe-4456-b96e-9f1772f393f6/12039DEST_PATH_IMAGE044.PNG "Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones")
![Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones](https://images-eureka.patsnap.com/patent_img/431918bd-efbe-4456-b96e-9f1772f393f6/122449DEST_PATH_IMAGE051.PNG "Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones")
Owner:SCHERING AG
Tetrahydro-1H-pyrrolo fused pyridones
ActiveUS8372863B2Increase productionReduce productionBiocideOrganic chemistryHif prolyl hydroxylasePyrrole
Owner:MERCK SHARP & DOHME LLC
Spiroazaindoles
Owner:MERCK SHARP & DOHME LLC
Tetrahydrofuropyridones
Owner:MERCK SHARP & DOHME LLC
Tetrahydro-1h-pyrrolo fused pyridones
ActiveUS20110009406A1Increased endogenous productionReduced endogenous productionBiocideOrganic chemistryProlyl HydroxylasesStereochemistry
The present invention relates to tetrahydro-1H-pyrrolo fused pyridone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Compositions and methods for treating anemia
InactiveCN105451739AImprove the level ofHeavy metal active ingredientsBiocideRegimenEnzyme inhibitor
Owner:AKEBIA THERAPEUTICS
Tetrahydrothieno pyridines
ActiveUS20110009425A1Increased endogenous productionReduced endogenous productionBiocideNervous disorderPyridineHif prolyl hydroxylase
The present invention relates to tetrahydrothienopyridine compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Substituted 4-hydroxypyrimidine-5-carboxamides
ActiveUS8278304B2Increase productionReduce productionBiocideOrganic chemistryProlyl HydroxylasesHif prolyl hydroxylase
Owner:MERCK SHARP & DOHME LLC
Tetrahydro-1H-pyrrolo fused pyridones
Owner:SCHERING AG
Substituted pyrimidines
Owner:MERCK SHARP & DOHME LLC +2
Substituted 4-hydroxypyrimidine-5-carboxamides
ActiveUS20120108600A1Increase productionReduce productionOrganic chemistryBlood disorderProlyl HydroxylasesHif prolyl hydroxylase
The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Tetrahydrothieno pyridines
ActiveUS8445680B2Increase productionReduce productionBiocideNervous disorderHif prolyl hydroxylaseProlyl Hydroxylases
Owner:MERCK SHARP & DOHME LLC
Inhibitors of hif prolyl hydroxylase
The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
Owner:MERCK SHARP & DOHME LLC +1
Substituted pyrimidines
The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:BIODURO BAONUO TECH BEIJING CO LTD +1
Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones
ActiveUS8921555B2Increase productionReduce productionBiocideOrganic chemistryCombinatorial chemistryHif prolyl hydroxylase
The present invention relates to substituted 1,3,8-triazaspiro[4.5]decame-2,4-diones useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
![Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones](https://images-eureka.patsnap.com/patent_img/cbc224f3-6a66-4975-b2cd-6bd3cf5a0a39/US08921555-20141230-C00001.png "Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones")
![Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones](https://images-eureka.patsnap.com/patent_img/cbc224f3-6a66-4975-b2cd-6bd3cf5a0a39/US08921555-20141230-C00002.png "Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones")
![Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones](https://images-eureka.patsnap.com/patent_img/cbc224f3-6a66-4975-b2cd-6bd3cf5a0a39/US08921555-20141230-C00003.png "Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones")
Owner:MERCK SHARP & DOHME LLC
Inhibitors of hif prolyl hydroxylase
The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
Owner:MSD R&D (CHINA) CO LTD +1
Substituted 4-hydroxypyrimidine-5-carboxamides
ActiveUS8815865B2Increase productionReduce productionOrganic chemistryBlood disorderProlyl HydroxylasesHif prolyl hydroxylase
Owner:MERCK SHARP & DOHME LLC
Co-crystal of an orally available HIF prolyl hydroxylase inhibitor
ActiveUS11192860B2Improve propertiesEfficient releaseOrganic chemistry methodsInorganic non-active ingredientsDiseaseEnzyme Inhibitor Agent
Owner:SANDOZ AG
Substituted pyrimidines
ActiveUS9079930B2Organic active ingredientsGroup 5/15 element organic compoundsCombinatorial chemistryHif prolyl hydroxylase
Owner:BIODURO BAONUO TECH BEIJING CO LTD +2
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