9 results about "Insulin regulation" patented technology

Provided herein are compositions comprising one or more substantially pure strains of bacteria as well as methods of making and using the same to treat and / or prevent one or more lipid and / or insulin related disorders and to regulate or alter the metabolism of lipids and / or insulin in a subject in need thereof.

The application discloses a blood glucose monitoring device and method capable of realizing continuous blood glucose monitoring and control. The monitoring method comprises the following steps: regulating the subcutaneous penetration state of insulin by changing the direction of an electric field applied to an insulin gel composition; wherein the insulin gel composition is communicated with a microneedle array composed of hollow microneedles, and the insulin gel composition comprises insulin, hyaluronic acid and a hydrogel. The application can realize automatic and continuous blood glucose monitoring and dynamic insulin regulation, and can be designed in the form of a skin patch for application by a patient, and has the advantages of small volume, high comfort and low cost.

The invention relates to an insulin-loaded hybrid nano-vesicle as well as a preparation method and application thereof. The hybrid nano-vesicle is obtained by hybridizing a milk-derived exosome and an insulin-loaded liposome. The milk-derived exosome and the liposome are creatively hybridized and used for co-loading and delivering insulin, the hybridized nano-vesicle can survive in a severe environment of gastrointestinal tracts and protect wrapped insulin, in intestinal tracts, the hybridized nano-vesicle interacts with FcRn on intestinal epithelial cells through surface IgG and triggers transendocytosis, and in addition, the exosome and the liposome can be used for co-loading and delivering insulin. The hybridized nano-vesicles have the advantages that a lysosome degradation pathway is avoided, then the hybridized nano-vesicles are effectively accumulated in the liver through portal veins, insulin is released in the liver to regulate blood sugar, and the hybridized nano-vesicles can be used for preparing insulin oral preparations.

The invention provides a Wuxian oral liquid and a preparation method thereof, and belongs to the field of traditional Chinese medicine preparations, the preparation method comprises the following steps: adding water into ginseng, bighead atractylodes rhizome, poria cocos, chrysanthemum, barbary wolfberry fruit, rehmannia root, dwarf lilyturf tuber, dried orange peel, kudzuvine root, fructus viticis and medicated leaven, decocting, mixing all decoctions, filtering, concentrating the filtrate under reduced pressure, adding xylitol and potassium sorbate, cooling the prepared liquid medicine to room temperature, and filling to obtain the Wuxian oral liquid. The sealed oral liquid is sterilized, cooled, wiped, subjected to light inspection, labeled and packaged, cane sugar and citric acid in an original formula are comprehensively replaced with xylitol, xylitol metabolism is not adjusted by insulin, the taste is cool, refreshing and sweet, the taste correction requirement can be met, and the taste of the oral liquid is improved. The medicine safety of diabetics and other people who avoid sugar is ensured, the application range of the product is greatly widened, the product is quantitatively filled, can be taken once a bottle is opened, is accurate in dosage, is convenient for the patient to carry about and take on time, and the treatment compliance of the patient is remarkably improved.

The present invention provides a combination comprising (a) a sulfonylurea; and (b) at least one of the following components: (i) an insulin modulator and (ii) an aldosterone antagonist, for example in combinations comprising (a) glibenclamide or a structural or functional analog thereof; and (b) at least one of the following components: (i) exenatide or a structural or functional analogue thereof or a pharmaceutically acceptable salt thereof; and (ii) potassium canlylate or a structural or functional analogue thereof. The combination is suitable for use in the treatment of stroke and other neurodegenerative conditions, as well as in the treatment and / or prevention of ischemia and / or reperfusion injury of various important organs, including the brain and heart. Other aspects of the invention relate to pharmaceutical products and pharmaceutical compositions comprising the combination according to the invention, as well as methods of treatment using the same.

The invention relates to an automatic dose recommendation method for an insulin intravenous injection system based on a big data AI algorithm. The method comprises the steps that patient information is added into the insulin intravenous injection system; selecting an insulin treatment mode as intravenous injection, and setting intravenous treatment parameters; calculating the next blood glucose detection time and an insulin regulatory factor according to the currently collected blood glucose value of the patient; on the basis of the calculation result, according to a system big data AI recommended insulin dosage algorithm, modeling processing is carried out, the insulin recommended dosage (infusion speed) of the current patient is calculated, and the patient is guided to accept medication and related matters needing attention to be reminded; and circulating the steps until the blood sugar of the patient reaches the target range. The invention further relates to a corresponding device, a processor and a storage medium thereof. By adopting the method, the device, the processor and the storage medium, an individualized, accurate and dynamic insulin regulation and control strategy can be customized for a patient, and the method, the device, the processor and the storage medium have important significance.