The invention relates to a formula of Hui-nationality traditional Chinese medicine akebia trifoliate esophagus cancer resisting tablets and a preparation method of the traditional Chinese medicine akebia trifoliate esophagus cancer resisting tablets. The medicine is green high-tech herbal medicine for treating esophagus cancer, is traditional Chinese medicine tablets prepared from akebia trifoliate, radix sophorae subprostratae, cortex acanthopanacis, cortex eucommiae and the like by mixing, decocting with water, extracting and concentrating according to a certain ratio, is mainly used for treating the esophagus cancer, and also can treat the digestive cancers such as pharyngolaryngeal cancer, stomach cancer, colorectal cancer and the like. The Hui-nationality traditional Chinese medicine akebia trifoliate esophagus cancer resisting tablets have the characteristics that the medicine and the dose are moderate, the selected herbs are proved in the modern medical pharmacological experiment to have an effect on treating the cancer, the expense is relatively low, the physical function can be fundamentally improved, the cell cancerization is prevented, and the physical health can be restored.