2results about How to "Mild separation conditions" patented technology

This invention discloses a tangential flow filtration separation device and a method for determining the drug content of liposomal drugs, relating to the field of liposomal drug filtration and determination technology. The device includes a filtration separation component, a gas control component, a drive component, and system piping and valve components. The filtration separation component includes a porous membrane filtration unit, with the inner cavity of the membrane forming a mother liquor flow path, and the outer cavity connected to a filtrate collection unit. The drive component is connected to the mother liquor flow path, and the gas control component is also connected to the mother liquor flow path. The system piping and valve components connect the filtration separation component, the gas control component, and the drive component to form a closed-loop flow path. This invention solves the problems of existing methods, such as difficulty in efficiently and stably separating free drugs from liposomal components, cumbersome operation, easy liposomal leakage, and sample loss and dilution, which seriously affect the accuracy of detection.

The application belongs to the field of acetonitrile and methanol homogeneous azeotrope separation, and particularly relates to a method and system for continuously separating acetonitrile and methanol mixture. The separation method comprises raw material pretreatment, extraction, methanol recovery and acetonitrile product refining process, so that acetonitrile, methanol and water can be efficiently separated. The separation system cooperating with the above separation method comprises a pretreatment unit, an extraction unit, a methanol recovery unit and an acetonitrile product refining unit. The pretreatment unit is used for removing impurities in the raw material. The extraction unit is used for extracting the raw material treated by the pretreatment unit, and separating an extraction phase and a raffinate phase. The methanol recovery unit is used for rectifying the extraction phase to obtain product methanol. The acetonitrile product refining unit is used for rectifying the raffinate phase to obtain product acetonitrile. In the application, inorganic salt extraction liquid is used to absorb methanol and water, and acetonitrile and methanol are efficiently rectified and purified. The application has the advantages of high product purity, high recovery rate, easy recovery of extraction agent, flexible process flow, economy and environmental protection, etc.