6results about How to "Strong creativity" patented technology

The application provides a high bulk natural color medical hand paper prepared from mechanical pulp and BCTMP and a preparation process, and relates to the technical field of household paper preparation. The application is aimed at solving the problems of high residual risk and poor bulk of existing bleached medical hand paper, unbalanced bulk performance, serious powder loss, lack of medical exclusive process, and insufficient safety of additives of natural color medical hand paper. The application adopts a ternary non-bleaching fiber compounding system of natural color broadleaf wood BCTMP, natural color mechanical pulp and natural color coniferous wood chemical pulp, constructs a double steady-state pre-control system of fiber conditioning pretreatment and pulp low-temperature curing, and adopts a low-damage coupling process of step-by-step additive addition, gradient gentle dewatering, low-pressure and low-temperature pressing, gradient low-tension drying and precise micro-creping to retain the three-dimensional bulk structure of the paper and strengthen the fiber bonding force. The application breaks the traditional performance balance problem, and the finished product has excellent bulk, dry and wet strength, low powder loss rate, no bleaching, less additive residue, safety and cleanliness, and is suitable for high-end medical scenes such as operating rooms and clean wards.

This invention discloses a chip manufacturing system and method based on global feature targeting. Using the inherent features of the workpiece itself in each chip manufacturing process as the sole targeting benchmark, it eliminates the need for dedicated alignment marks, calibration boards, standard templates, and manual calibration. Through unified feature acquisition, feature targeting calculation, dynamic closed-loop correction, and full-process collaborative control, it achieves integrated precision manufacturing across the entire process, including wafer cleaning, thin film deposition, photolithography alignment, etching, ion implantation, annealing, CMP polishing, defect detection and repair, advanced packaging bonding, measurement, transmission, and sorting. The system consists of a global feature sensing unit, a feature targeting calculation center, a full-process collaborative control unit, a multi-process precision execution unit, and a full-process closed-loop feedback optimization unit. It adopts a coaxial common field of view, common motion platform, unified clock synchronization, and vacuum-compatible integrated architecture, adapting to advanced processes of 3nm and below. The overlay error is improved by ≥20% compared to existing solutions, significantly improving manufacturing accuracy, yield, and efficiency, reducing equipment dependence and production costs, and forming a fundamental technological barrier for the entire chip manufacturing process.

The application discloses application of a colorant with a Trichoderma viride metabolic product as an effective component to promote fruit coloring. The Trichoderma viride metabolic product is prepared by fermentation of a Trichoderma viride strain (CGMCC 3.11450), and the obtained Trichoderma viride metabolic product has a significant promoting effect on fruit coloring. When the Trichoderma viride metabolic product is used in combination with an emulsifier, a dispersing agent and a calcium-containing foliar fertilizer / fruit surface fertilizer, the fruit skin hardness can be enhanced, anthocyanin accumulation can be promoted, and the coloring rate can be improved. The Trichoderma viride metabolic product is creatively applied to promote fruit coloring, the fermentation process is mature, the raw material cost is low, the product is fast, large, stable, the preparation is natural and environment-friendly, the coloring effect is significant, the development and utilization of the beneficial bacteria in agricultural use are widened, a green and environment-friendly biological source preparation for fruit coloring is provided, and the application has good development and application prospect and practical significance.

This invention belongs to the field of trastuzumab technology, specifically relating to a Nod2 gene knockout CHO cell line, its preparation method, and its applications. The Nod2 gene in the knockout CHO cells is lost. The CHO cells stably express trastuzumab before Nod2 gene knockout. At the same cell density, the CHO cell line shows a 1.22-1.55-fold increase in trastuzumab expression. This invention knocks out the Nod2 gene in CHO cells using a CRISPR / Cas9 system, and also provides a method for constructing the cell line, a method for producing trastuzumab using the cell line, and applications of the cell line. The Nod2 gene knockout cell line significantly increases trastuzumab expression in suspension culture while effectively reducing the aggregation level of the target protein. Furthermore, the high-yield trastuzumab trait is stably inherited and does not significantly inhibit normal cell growth, providing a new stable platform for efficient trastuzumab production and possessing significant industrial application value.

The application relates to a question and scheduling method and system, and belongs to the technical field of natural language processing and intelligent scheduling. The method comprises the following steps: acquiring question interaction multi-source state data, setting quantifiable monitoring indexes and three-level judgment standards in each dimension, and constructing a hierarchical process monitoring mechanism; preprocessing multi-source data, building a multi-dimensional state recognition model, judging the state level according to the standards and outputting a research and judgment result; constructing a strategy set, continuously monitoring state changes, constructing a state feature vector and a strategy parameter vector; executing a scheduling action, acquiring feedback evaluation effect, correlating and storing related data and calculating strategy matching degree, and iteratively optimizing monitoring indexes and judgment standards. The application realizes accurate perception and scientific research and judgment of multi-dimensional states in the whole process of question interaction, solves the pain points of rigidity, lack of whole-process monitoring and iteration ability of the prior art, and is suitable for various intelligent question interaction scenes.

The present application relates to the use of a cyclic heptapeptide in the preparation of a medicament for reducing body weight. Specifically, the present application discloses a new use of a cyclic heptapeptide Cyclo-[TYVPKAF] or a pharmaceutically acceptable salt thereof in the preparation of a medicament for reducing body weight, preventing or treating a body weight related disease. The body weight related disease includes obesity, overweight, metabolic syndrome, type 2 diabetes, fatty liver, cardiovascular disease or osteoarthritis, etc. The present application first discovers that the specific cyclic heptapeptide has clear and convenient body weight control activity, and in particular, its orally effective characteristics provide a new choice for long-term body weight management.