Application of Nepider in preparing medicine to accelerate ejection of calculus for urinary system

Abstract

An application of the naftopidil in preparing the lithagogue for the calculi in urinary system, especially the calculi in lower segment of ureter and the broken calculi, is disclosed.

Description

technical field [0001] The invention relates to the application of naftopidil, in particular to the application of naftopidil in the preparation of medicines for promoting the excretion of urinary stones. Background technique [0002] Urinary calculi play an important role in clinical practice. According to statistics in Europe and North America, about 8-15% of people will suffer from urolithiasis in their lifetime. There are many treatment methods for stone disease, including drug therapy, non-surgical treatment and surgical treatment. [0003] Because stones are easy to recur and surgery is painful, more and more people are reluctant to undergo surgery. Since the first clinical application of extracorporeal shock wave lithotripsy (ESWL) in 1980, ESWL has become the first choice for non-surgical treatment of stone disease. Calculus drug therapy mainly includes dissolving stones, preventing stones and removing stones. Stone removal therapy is commonly used in traditional...

AI Technical Summary

Problems solved by technology

[0006] The currently clinically used stone-removing drugs mainly include calcium ion channel blockers (nifedipine), prostaglandin synthase inhibitors (indomethacin, diclofenac sodium), hormones (sex hormones and corticosteroid hormones) and some other drugs ( Such as Chinese herbal medicine, etc.), but due to the shortcomings of these drugs, such as ineffective curative effect and relatively large side effects, the clinical application is limited

[0007] Naftopidil is mainly used in the treatment of hypertension and benign prostatic hyperplasia, and there is no report on using naftopidil as a stone-discharging drug in the urinary system