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Polylactic acid microglobule Chinese medicine compound used for treating bone arthritis

A technology of polylactic acid microspheres and osteoarthritis, which is applied in the fields of pharmaceutical formulations, bone diseases, drug combinations, etc., can solve the problems of large side effects, etc., and achieve the effect of strong effect, long-lasting effect, and increased drug concentration

Inactive Publication Date: 2009-02-04
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, when Western medicine treats osteoarthritis, although the curative effect is obvious, the side effects are relatively large. In the long-term and large amount of clinical practice, traditional Chinese medicine has accumulated rich experience in the treatment of osteoarthritis and achieved satisfactory curative effect.

Method used

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  • Polylactic acid microglobule Chinese medicine compound used for treating bone arthritis
  • Polylactic acid microglobule Chinese medicine compound used for treating bone arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Preparation of "Guyan No. 1" polylactic acid microspheres

[0013] The invention adopts double emulsion-solvent volatilization method to prepare "Guyan No. 1" polylactic acid microspheres, that is, polylactic acid is dissolved in methylene chloride to form an organic phase, and an appropriate amount of gelatin is dissolved in the concentrated extract of "Guyan No. 1" to form Water phase, add the water phase to the organic phase, stir and homogenize to form colostrum (W / O), then transfer the colostrum into the aqueous solution containing PVA, stir to form double emulsion (W / O / W), remove the organic solvent, centrifuge The microspheres were separated by filtration and dried under reduced pressure to obtain the "Guyan No. 1" polylactic acid microspheres. Wherein the gelatin concentration is 8%, the volume ratio of the inner water phase and the oil phase is 2:5, the stirring speed during dispersion is 1200r / min, and the polylactic acid concentration is 20%.

Embodiment 2

[0014] Example 2 Determination of Drug Loading Capacity and Encapsulation Efficiency of "Guyan No. 1" Polylactic Acid Microspheres

[0015] The contents of psoralen and isopsoralen were determined by high performance liquid chromatography. The chromatographic condition is that the chromatographic column is Dramonsid TM -C 18 Column (250mm×4.6mm, 5μm, Dima Company), mobile phase is methanol-1% acetic acid (60:40), flow rate: 0.8ml min -1 ; Detection wavelength: 245nm; Column temperature: room temperature. The test solution is to accurately weigh about 0.1g of the polylactic acid microsphere sample of Bone Yan No. 1, put it in a stoppered Erlenmeyer flask, add 10ml of methanol, seal it tightly, weigh it, soak it overnight, extract it by ultrasonic for 30min, let it cool, add Make up the lost weight with methanol, filter, discard the initial filtrate, and continue to filter the filtrate through a 0.45 μm membrane filter. Get the test solution 10μl into the chromatograph, calc...

Embodiment 3

[0019] Example 3 Observation on the Morphology, Particle Size and Distribution of Polylactic Acid Microspheres "Guyan No. 1"

[0020] The appearance of the microspheres was observed with an optical microscope and an electron scanning microscope, and the particle size and particle size distribution of the microspheres were investigated with a microscopic counting method, and each count was not less than 500 particles.

[0021] Observed under optical microscope and scanning electron microscope ( figure 1 ), the shape of "Guyan No. 1" microspheres is round, the surface is smooth, and the distribution is even.

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Abstract

A Chinese medicine in the form of polylactic acid microballs for treating osteoarthritis features that its active components are contained in each microball for slow releasing and selective absorption.

Description

technical field [0001] The invention relates to a polylactic acid microsphere of a traditional Chinese medicine compound. The invention also relates to a preparation method of the polylactic acid microspheres of the above-mentioned traditional Chinese medicine compound. Background technique [0002] Osteoarthritis (osteoarthritis) is the most common joint disease in the world, according to statistics, 80% of people over 60 years old are affected by it. With the aging of the population, the incidence of osteoarthritis is increasing, which seriously affects the social labor force and the quality of life of patients. At present, Western medicine has obvious curative effect in the treatment of osteoarthritis, but it has relatively large side effects. In the long-term and large amount of clinical practice, traditional Chinese medicine has accumulated rich experience in the treatment of osteoarthritis and achieved satisfactory curative effect. The traditional Chinese medicine tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/487A61K36/296A61K36/232A61K9/14A61K47/34A61P19/02
Inventor 杨帆李明亚金描真
Owner GUANGDONG PHARMA UNIV
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