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Erigeron breviscapus ketone ester and its injection preparation process

A technology of asarone ester and scutellaria scutellariae, which is applied in the field of traditional Chinese medicine, can solve the problems of unreasonable extraction and separation process, large loss of components, large waste of resources, etc., and achieves less toxic side effects and adverse reactions, high blood drug concentration and high quality. controllable effect

Inactive Publication Date: 2009-02-18
四川三民药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Erigeron breviscapitalis contains two types of active ingredients, flavonoids and caffeic acid esters. Erigeron breviscapus injection mainly contains caffeic acid esters, and the content of wild scutellarin is less, which is equivalent to 3g of medicinal materials, containing 20-30mg of caffeic acid esters, containing The scutellarin was calculated as 2-4 mg, which indicated that the extraction and separation process of the existing scutellarin injection was unreasonable, and the flavonoid components of scutellarin were greatly lost; while the scutellarin injection mainly contained scutellarin flavonoids, and no Contains caffeic acid ester components, each 10ml, equivalent to 4g of medicinal materials, contains 20mg of scutellarin; the high-performance liquid diode array detection (HPLC-DAD) diagrams of breviscapine injection and breviscapine injection have significant the difference
Therefore, the loss of scutellarin flavonoids in the original breviscapine injection fed with medicinal materials is too high, which wastes resources, and the preparation process of breviscapine injection fed with total flavonoids completely wastes the loss of caffeic acid esters in the effective parts , a greater waste of resources

Method used

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  • Erigeron breviscapus ketone ester and its injection preparation process
  • Erigeron breviscapus ketone ester and its injection preparation process
  • Erigeron breviscapus ketone ester and its injection preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A

[0041] Example A Small-capacity breviscapine ester injection

[0042] Example 1 is composed of 100 mg of Erigeron breviscapine ester and 5 ml of water for injection.

[0043] Example 2 consists of 200 mg of breviscapine ester and 10 ml of water for injection.

[0044] The large-capacity breviscapine ester sodium chloride injection is prepared according to the following method to prepare the finished product:

[0045] Take breviscapine ester 100~200mg, add 0.9% (W / V) sodium chloride of the total amount of injection, add about 20% of the prescription amount of water for injection, adjust the pH to about 7.0, heat and boil, add 0.3% (W / V) Activated carbon adsorption for about 10min, filter and decarbonize, add water for injection to the full amount, adjust the pH to about 7.0, finely filter and clear, fill and seal in 50-100ml infusion bottle, sterilization, light inspection, labeling, finished product Get it after inspection and packaging.

Embodiment B

[0046] Example B Large-capacity breviscapine ester sodium chloride injection

[0047] Example 1 It consists of 100 mg of scutellarin ester, 0.45 g of sodium chloride, and 50 ml of water for injection.

[0048] Example 2 consists of 200 mg of scutellarin, 0.9 g of sodium chloride, and 100 ml of water for injection.

[0049] The large-capacity breviscapine ester glucose injection is prepared according to the following method to prepare the finished product:

[0050] Take 100-200 mg of breviscapine ester, add 5% (W / V) glucose of the total amount of injection, add about 20% of the prescription amount of water for injection, adjust the pH to about 6.0, heat and boil, add 0.3% (W) / V) Activated carbon adsorption for about 10min, filter and decarbonize, add water for injection to the full amount, adjust the pH to about 6.0, finely filter and clear, after the semi-finished product has passed the inspection, fill it in a 50-100ml infusion bottle, sterilize, light inspection, and paste Get ...

Embodiment C

[0051] Example C Large-capacity breviscapine ester glucose injection

[0052] Example 1 It consists of 100 mg of breviscapine ester, 2.5 g of glucose, and 50 ml of water for injection.

[0053] Example 2 is composed of 200 mg of breviscapine ester, 5 g of glucose, and 100 ml of water for injection.

[0054] The large-capacity breviscapine ester glycerol injection is prepared according to the following method to prepare the finished product:

[0055] Take breviscapine ester 100~200mg, add 2.6% (W / V) glycerin of the total amount of injection, add about 20% of the prescription water for injection, adjust the pH to about 7.0, heat and boil, add 0.3% / V) Activated carbon is adsorbed for about 10 minutes, filtered and decarbonized, add water for injection to the full amount, finely filter and clear, after the semi-finished product is inspected, fill it in a 50-100ml infusion bottle, sterilize, light inspection, labeling, finished product inspection, and packaging Immediately.

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Abstract

The invention provides a process for extracting fleabane ketonic ester, the effective component of fleabane, and a process for preparing the fleabane ketonic ester injection. The fleabane ketonic ester comprises 50% of flavones and 40% of caffeic acid esters, and the extraction process consists of ethanol backflow abstraction, condensing, adjusting pH, alcohol deposition, concentrating supernatant fluid, passing through polyamide column, alcohol scrubbing, reclaiming the ethanol, mixing the obtained caffeic acid ester with three time total deposition, charging water for injection, adjusting pH, finally concentrating and drying. The injection comprises fleabane ketonic ester, medicinal auxiliary material and water for injection, and can be prepared into the forms of small injection, fluid infusion agent and freeze dried injection.

Description

Technical field: [0001] The invention relates to a preparation method of the effective part breviscapine ketone ester extracted from breviscapine medicinal materials and its injection, and belongs to the technical field of traditional Chinese medicine. The invention has the functions of invigorating the heart, invigorating the brain, promoting blood circulation, removing blood stasis, and relaxing the collaterals and relieving pain. It is mainly used to treat chest pain and heartache syndrome (coronary heart disease angina pectoris), stroke (ischemic stroke and stroke sequelae) caused by the deficiency of righteous qi and blood stasis and pulse obstruction. Background technique: [0002] The syndrome of chest pain and heartache referred to in the theory of Chinese medicine includes chest tightness, chest pain, palpitations, shortness of breath, fatigue and laziness, shortness of breath when moving, dull or dull complexion, upset saliva, red and dark tongue or purple, heavy and su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K36/28A61K9/08A61K9/19A61P9/10
Inventor 罗明生
Owner 四川三民药业有限公司