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Medicament for treating ulcerative colitis and preparation process thereof

A technology for ulcerative colitis and drugs, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve the problems of inconvenient medication and achieve the effects of no toxic side effects, pain relief, and good therapeutic effects

Inactive Publication Date: 2009-06-17
JINZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine therapy adopts traditional Chinese medicine or enema method, and traditional Chinese medicine oral administration mostly uses powder or decoction, such as Xileisan, Wenshen Fupi Decoction, etc. Although good curative effect has been achieved, due to the accumulation of rectal and distal For the colon, it is difficult to concentrate the medicine on the lesion when taking decoction or powder orally. However, in the treatment of enema with traditional Chinese medicine, although the medicine can directly act on the lesion, it is very inconvenient to use.

Method used

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  • Medicament for treating ulcerative colitis and preparation process thereof
  • Medicament for treating ulcerative colitis and preparation process thereof
  • Medicament for treating ulcerative colitis and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, prepare the medicine for the treatment of ulcerative colitis

[0027] The preparation method of the medicine for the treatment of ulcerative colitis of capsule dosage form of the present invention, comprises the following steps:

[0028] 1) Weigh 400g of Puhuang, 260g of Galla gall, and 200g of Sophora flavescens;

[0029] 2) Mix Pollen and Sophora flavescens in 70% ethanol with a volume ratio of 1:5, cold soak for 12 hours, then heat the ethanol extract to reflux twice for 2 hours each time, combine the filtrates obtained from the 2 times of reflux Filtrate, recover ethanol, concentrate under reduced pressure to dryness, pulverize and set aside;

[0030] 3) decoct Galla gallnuts with water for 2 times, decoct with 5 times of water for 1 hour for the first time, and decoct with 4 times of water for 1 hour for the second time, combine the water extract, filter the water extract and concentrate to a relative density of 1.05, mix the concentrated liquid wit...

Embodiment 2

[0032] Embodiment 2, prepare the medicine for the treatment of ulcerative colitis

[0033] The preparation method of the medicine for the treatment of ulcerative colitis of capsule dosage form of the present invention, comprises the following steps:

[0034] 1) Weigh 440g of Puhuang and 320g of Chinese Gallnut;

[0035] 2) Mix Puhuang and Sophora flavescens in 90% ethanol with a volume ratio of 1:4, cold soak for 36 hours, then heat the ethanol extract to reflux for 3 times, the first and second times for 2 hours, the third time for 1 hour, The filtrates obtained by reflux for three times are combined and filtered, the ethanol is recovered, concentrated to dryness, pulverized and packed into enteric-coated capsules to obtain the medicine for treating ulcerative colitis in the form of capsules.

Embodiment 3

[0036] Embodiment 3, prepare the medicine for treating ulcerative colitis

[0037] The preparation method of the medicine for the treatment of ulcerative colitis of capsule dosage form of the present invention, comprises the following steps:

[0038] 1) Weigh 420g of Puhuang, 240g of Galla gall, 120g of Sophora flavescens;

[0039] 2) Mix Pollen and 60% ethanol with a volume ratio of 1:6, cold soak for 24 hours, then heat the ethanol extract to reflux for 1.5 hours, filter the filtrate obtained by reflux, recover ethanol, and concentrate to dryness , after being crushed for later use;

[0040] 3) Decoct Galla gallnuts with water for 4 times, the first time with 10 times of water for 3 hours, the second time with 8 times of water for 2 hours, the third time with 6 times of water for 1 hour, and the fourth time with Decoct with 4 times water for 1 hour, combine the water extracts, filter the water extracts and concentrate to a relative density of 1.2, mix the thick paste obtai...

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Abstract

The invention relates to a medicament for treating ulcerative colitis and process for preparation, wherein the constituents of the raw materials include (by weight ratio) cattail pollen 7-11 parts, schisandra fruit 4-8 parts, and flavescent sophora root 2-6 parts.

Description

technical field [0001] The invention relates to a medicine for treating ulcerative colitis and a preparation method thereof, in particular to a medicine for treating ulcerative colitis prepared from Chinese herbal medicine and a preparation method thereof. Background technique [0002] Ulcerative colitis is a chronic colitis of unknown cause. Lesions mainly occur in the mucosa of the colon, mainly ulcers, and can spread throughout the entire colon in severe cases, and the mortality rate is high in the acute phase, and it is easy to cause cancer in the chronic phase. The main clinical symptoms are: diarrhea, pus and blood in the stool, abdominal pain and tenesmus. Most of the patients with this disease are young and middle-aged, and the course of the disease is slow and long, the severity of the disease varies, and it often recurs. Modern medicine believes that the disease is caused by autoimmune abnormalities leading to the destruction of the mucous membranes, or mental fa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61K36/489A61K35/64A61P1/00A61P1/04
Inventor 王洪新张波杨菁
Owner JINZHOU MEDICAL UNIV