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Medicinal composition containing rosuvastatin or pitavastatin and B vitamin series

A technology of rosuvastatin and pitavastatin, which is applied in the field of pharmaceutical preparation, and achieves the effects of improving compliance, taking medicines conveniently, and not increasing toxicity

Active Publication Date: 2009-06-24
SHENZHEN AUSA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, judging from the 9-30% reduction in total mortality and the 24-37% reduction in coronary events, the prevention and treatment strategies for coronary heart disease still need to be further improved

Method used

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  • Medicinal composition containing rosuvastatin or pitavastatin and B vitamin series
  • Medicinal composition containing rosuvastatin or pitavastatin and B vitamin series
  • Medicinal composition containing rosuvastatin or pitavastatin and B vitamin series

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of rosuvastatin folic acid tablets

[0027] Prescription: Rosuvastatin Calcium 10g

[0028] Folic acid 0.4g

[0029] Lactose 50g

[0030] Starch 50g

[0031]Sodium Carboxymethyl Starch 20g

[0032] 10% starch syrup

[0033] Magnesium stearate amount

[0034] Preparation method: pulverize the original and auxiliary materials through a 120-mesh sieve, weigh the prescription amounts of rosuvastatin calcium, folic acid, lactose, starch and sodium carboxymethyl starch, pulverize and sieve, mix evenly, and use an appropriate amount of 10% starch slurry to make The soft material is granulated, dried at 40°C to 60°C until the water content is about 3%, taken out, granulated, mixed with an appropriate amount of magnesium stearate, and pressed into 1000 pieces according to the conventional method.

Embodiment 2

[0035] Example 2 Preparation of Rosuvastatin Folic Acid Tablets

[0036] Prescription: Rosuvastatin Calcium 20g

[0037] Folic acid 0.8g

[0038] Microcrystalline Cellulose 60g

[0039] Pregelatinized starch 40g

[0040] Micropowder silica gel

[0041] Magnesium stearate amount

[0042] Preparation method: pulverize the original and auxiliary materials through a 120-mesh sieve, weigh the prescription amounts of rosuvastatin calcium, folic acid, microcrystalline cellulose, pregelatinized starch, micropowder silica gel and magnesium stearate, mix evenly, and directly press the powder into 1000 pieces are available.

Embodiment 3

[0043] Example 3 Preparation of Rosuvastatin Folic Acid Capsules

[0044] Prescription: Rosuvastatin Calcium 40g

[0045] Calcium leucovorin 5g

[0046] Microcrystalline Cellulose 50g

[0047] Starch 50g

[0048] PVP 20g

[0049] 10% starch syrup

[0050] Micropowder silica gel

[0051] Preparation method: pulverize the original and auxiliary materials through a 120-mesh sieve, weigh the prescription amounts of rosuvastatin calcium, calcium leucovorin, lactose starch and PVP, pulverize and sieve, mix evenly, and use an appropriate amount of 10% starch slurry to make Soft material, granulated, dried at 40°C to 60°C until the water content is about 3%, taken out, granulated, mixed with an appropriate amount of talc, and filled with 1,000 capsules according to conventional methods.

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing rosuvastatin or pitavastatin compounds and B vitamins; wherein the content of rosuvastatin or pitavastatin compounds is 1-40 mg, and the content of B vitamins is 0.1-50 mg . The invention also provides the application of the pharmaceutical composition in the preparation of medicines for preventing, treating and delaying atherosclerosis and related cardiovascular and cerebrovascular diseases. The invention has the advantages that the curative effect of the statin lipid-lowering drugs can be improved, the vascular endothelial protection and anti-atherosclerosis aspects are superior to the statin lipid-lowering drugs, the side effects of the statin lipid-lowering drugs are reduced, and the toxicity is not increased, In addition, it can make it convenient for patients to take medicines and reduce medical expenses.

Description

technical field [0001] The invention provides a pharmaceutical composition containing rosuvastatin or pitavastatin and B vitamins, and the use of the pharmaceutical composition in preparing medicine. belongs to the field of pharmacy. Background technique [0002] Cardiovascular diseases are the first or second cause of death in my country, and the morbidity and mortality of coronary heart disease are on the rise. Several risk factors, such as hyperlipidemia, hypertension, smoking, and diabetes, play an important role in the pathogenesis of coronary heart disease. Among them, hypercholesterolemia can cause and accelerate atherosclerosis. As one of the main risk factors of coronary heart disease, it has already attracted extensive attention. Epidemiological studies have confirmed that the increase of total cholesterol level is positively correlated with the risk of coronary heart disease death; the prevalence of coronary heart disease in patients with cholesterol <5.2mmol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/505A61K31/714A61K31/519A61K9/16A61K9/20A61K9/48A61P9/10A61K31/47
Inventor 陈光亮王琳琳
Owner SHENZHEN AUSA PHARM CO LTD
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